期刊
FRONTIERS IN ONCOLOGY
卷 10, 期 -, 页码 -出版社
FRONTIERS MEDIA SA
DOI: 10.3389/fonc.2020.608923
关键词
immune reconstitution; unconventional T cells; microbiome; allogeneic transplantation; mucosal invariant T cells (MAIT) cells; γ δ T cells; invariant NK T (iNKT) cells
类别
资金
- NCI
- MSKCC Cancer Center Core Grants [P30 CA008748, R01-CA228358, R01-CA228308, P01-CA023766]
- NHLBI [R01-HL125571, R01-HL123340]
- NIA National Institute of Aging [P01-AG052359]
- NIAID [U01 AI124275]
- Tri-Institutional Stem Cell Initiative award [2016-013]
- Lymphoma Foundation
- Parker Institute for Cancer Immunotherapy at Memorial Sloan Kettering Cancer Center
- Parker Institute for Cancer Immunotherapy
- Deutsche Forschungsgemeinschaft (DFG)
- Susan and Peter Solomon Divisional Genomics Program
- DKMS
Allogeneic hematopoietic cell transplantation (allo-HCT) is a treatment for hematologic malignancies, but its broader implementation is limited by high rates of complications and mortality. Reconstitution of the immune system is crucial for good long-term outcomes. Unconventional T cells may play an important immunomodulatory role after allo-HCT.
Allogeneic hematopoietic cell transplantation (allo-HCT) is performed as curative-intent therapy for hematologic malignancies and non-malignant hematologic, immunological and metabolic disorders, however, its broader implementation is limited by high rates of transplantation-related complications and a 2-year mortality that approaches 50%. Robust reconstitution of a functioning innate and adaptive immune system is a critical contributor to good long-term patient outcomes, primarily to prevent and overcome post-transplantation infectious complications and ensure adequate graft-versus-leukemia effects. There is increasing evidence that unconventional T cells may have an important immunomodulatory role after allo-HCT, which may be at least partially dependent on the post-transplantation intestinal microbiome. Here we discuss the role of immune reconstitution in allo-HCT outcome, focusing on unconventional T cells, specifically mucosal-associated invariant T (MAIT) cells, gamma delta (gd) T cells, and invariant NK T (iNKT) cells. We provide an overview of the mechanistic preclinical and associative clinical studies that have been performed. We also discuss the emerging role of the intestinal microbiome with regard to hematopoietic function and overall immune reconstitution.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据