期刊
FRONTIERS IN ONCOLOGY
卷 10, 期 -, 页码 -出版社
FRONTIERS MEDIA SA
DOI: 10.3389/fonc.2020.570916
关键词
tRNA-derived fragment; gastric cancer; lymph node metastasis; NELL2; molecular mechanism
类别
资金
- Natural Science Foundation of China [81872031]
- Major R&D Plan of Liaoning Province [2019JH1/10300007]
- Xingliao Talents Program in Liaoning Province [XLYC1807164]
- Scientific and technological innovation talents program of Shenyang [RC190202]
This study found that higher levels of tRF-3017A were associated with significantly higher lymph node metastasis in gastric cancer patients, and tRF-3017A may play a role in promoting the migration and invasion of gastric cancer cells by silencing the tumor suppressor NELL2.
tRNA-derived fragments (tRFs) are a new classification of small non-coding RNAs (sncRNAs) derived from the specific cleavage of precursors and mature tRNAs. Accumulating recent evidence has shown that tRFs are frequently abnormal in several cancers. Nevertheless, the role of tRFs in gastric cancer and its mechanism remain unclear. In this study, we found abnormal expression of tRF-3017A (derived from tRNA-Val-TAC) in gastric cancer tissues and cell lines and confirmed its effect on promoting the invasion and migration of gastric cancer cells through functional experiments in vitro. Analysis of clinicopathologic data showed patients with higher tRF-3017A were associated with significantly higher lymph node metastasis. Mechanistic investigation implies that tRF-3017A regulates the tumor suppressor gene NELL2 through forming the RNA-induced silencing complex (RISC) with Argonaute (AGO) proteins. In this study, we found that higher tRF-3017A were associated with significantly higher lymph node metastasis in gastric cancer patients and the tRF-3017A may play a role in promoting the migration and invasion of gastric cancer cells by silencing tumor suppressor NELL2.
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