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Multiple roles for lipids in the Hedgehog signalling pathway
Suzanne Eaton
NATURE REVIEWS MOLECULAR CELL BIOLOGY (2008)
Bax activation and stress-induced apoptosis delayed by the accumulation of cholesterol in mitochondrial membranes
S. Lucken-Ardjomande et al.
CELL DEATH AND DIFFERENTIATION (2008)
High dose Simvastatin does not reverse resistance to Vincristine, Adriamycin, and Dexamethasone (VAD) in Myeloma
E. van der Spek et al.
HAEMATOLOGICA (2007)
Activation of the PTEN/mTOR/STAT3 pathway in breast cancer stem-like cells is required for viability and maintenance
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PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2007)
Inhibition of HMGcoA reductase by atorvastatin prevents and reverses MYC-induced lymphomagenesis
Catherine M. Shachaf et al.
BLOOD (2007)
First clinical experience with simvastatin to overcome drug resistance in refractory multiple myeloma
Ralf Schmidmaier et al.
EUROPEAN JOURNAL OF HAEMATOLOGY (2007)
Blockade of adaptive defensive changes in cholesterol uptake and synthesis in AME by the addition of pravastatin to idarubicin plus high-dose Ara-C: a phase 1 study
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BLOOD (2007)
Determinants of sensitivity to lovastatin-induced apoptosis in multiple myeloma
W. Wei-Lynn Wong et al.
MOLECULAR CANCER THERAPEUTICS (2007)
Statin-induced apoptosis and skeletal myopathy
Amie J. Dirks et al.
AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY (2006)
AMPK and cell proliferation - AMPK as a therapeutic target for atherosclerosis and cancer
Hiroyuki Motoshima et al.
JOURNAL OF PHYSIOLOGY-LONDON (2006)
Statin therapy and autoimmune disease: from protein prenylation to immunomodulation
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NATURE REVIEWS IMMUNOLOGY (2006)
Efficacy and safety of cholesterol-lowering treatment: prospective meta-analysis of data from 90,056 participants in 14 randomised trials of statins
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LANCET (2005)
Transcriptional regulation and transformation by MYC proteins
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NATURE REVIEWS MOLECULAR CELL BIOLOGY (2005)
Choline kinase is a novel oncogene that potentiates RhoA-induced carcinogenesis
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CANCER RESEARCH (2005)
Statins and the risk of colorectal cancer
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NEW ENGLAND JOURNAL OF MEDICINE (2005)
A signalling pathway controlling c-Myc degradation that impacts oncogenic transformation of human cells
E Yeh et al.
NATURE CELL BIOLOGY (2004)
Cholesterol synthesis and import contribute to protective cholesterol increments in acute myeloid leukemia cells
DE Banker et al.
BLOOD (2004)
Drug repositioning: Identifying and developing new uses for existing drugs
TT Ashburn et al.
NATURE REVIEWS DRUG DISCOVERY (2004)
AGTPase-activating protein binds STAT3 and is required for IIL-6-induced STAT3 activation and for differentiation of a leukemic cell line
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BLOOD (2004)
The AMP-activated protein kinase cascade - a unifying system for energy control
D Carling
TRENDS IN BIOCHEMICAL SCIENCES (2004)
Rheb GTPase is a direct target of TSC2 GAP activity and regulates mTOR signaling
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GENES & DEVELOPMENT (2003)
Cholesterol-modulating agents kill acute myeloid leukemia cells and sensitize them to therapeutics by blocking adaptive cholesterol responses
HY Li et al.
BLOOD (2003)
TSC2 is phosphorylated and inhibited by Akt and suppresses mTOR signalling
K Inoki et al.
NATURE CELL BIOLOGY (2002)
HMG-CoA reductase inhibitors and the malignant cell: the statin family of drugs as triggers of tumor-specific apoptosis
WWL Wong et al.
LEUKEMIA (2002)
Simultaneous tyrosine and serine phosphorylation of STAT3 transcription factor is involved in Rho A GTPase oncogenic transformation
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MOLECULAR BIOLOGY OF THE CELL (2001)
Rac1 mediates STAT3 activation by autocrine IL-6
TR Faruqi et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2001)
Regulation of STAT3 by direct binding to the Rac1 GTPase
AR Simon et al.
SCIENCE (2000)