期刊
FRONTIERS IN ONCOLOGY
卷 11, 期 -, 页码 -出版社
FRONTIERS MEDIA SA
DOI: 10.3389/fonc.2021.628359
关键词
hyperglycemia; chemotherapy resistance; chemoresistance; breast cancer; glucose metabolism
类别
资金
- Chinese National Natural Science Funds [81973861]
- Key Project for Medical and Health in Zhejiang Province [2016ZDA004]
- Zhejiang Medicine and Health Technology Plan Project [WKJ-ZJ-1803-01-XM]
- Medical and Health Projects in Zhejiang Province [2020KY495]
- Zhejiang Traditional Chinese Medicine Project [2020 ZQ 009-QZ]
- [WKJ-ZJ-2116]
This article focuses on the mechanisms of chemotherapy resistance in hyperglycemic breast cancer patients, including abnormal behaviors of cancer cells in the hyperglycemic microenvironment and the impact of abnormal glucose metabolism on key signaling pathways. Understanding the causes of drug resistance in hyperglycemic patients may help to better inform the development of effective treatments.
Female breast cancer is a complex, multifactorial disease. Studies have shown that hyperglycemia is one of the most important contributing factors to increasing the risk of breast cancer that also has a major impact on the efficacy of chemotherapy. At the cellular level, hyperglycemia can promote the proliferation, invasion, and migration of breast cancer cells and can also induce anti-apoptotic responses to enhance the chemoresistance of tumors via abnormal glucose metabolism. In this article, we focus on the latest progress in defining the mechanisms of chemotherapy resistance in hyperglycemic patients including the abnormal behaviors of cancer cells in the hyperglycemic microenvironment and the impact of abnormal glucose metabolism on key signaling pathways. To better understand the advantages and challenges of breast cancer treatments, we explore the causes of drug resistance in hyperglycemic patients that may help to better inform the development of effective treatments.
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