期刊
FRONTIERS IN ONCOLOGY
卷 11, 期 -, 页码 -出版社
FRONTIERS MEDIA SA
DOI: 10.3389/fonc.2021.609397
关键词
SEER; surgery; prognosis; propensity score matching analysis; primary hepatic carcinoid tumor
类别
资金
- National Natural Science Foundation of China [81400679]
- Guangdong Natural Science Foundation [2014A030310067]
- Guangzhou Science and Technology Programs [202002030387, 201704020153]
- Special fund of Foshan Summit plan [2019D006]
- Foundation of Basic and Applied Basic Research of Guangdong Province [2020A1515110073]
Primary hepatic carcinoid tumor (PHCT) is rare with unclear clinical characteristics and prognosis. Surgical intervention is an independent predictor for better prognosis in PHCT patients, while females may have a higher susceptibility to PHCT with a better outcome.
Background Primary hepatic carcinoid tumor (PHCT) is rare and has unclear clinical characteristics and prognosis. Methods A retrospective study using data from the SEER database for patients diagnosed with PHCT used univariate and multivariate Cox models to screen for independent prognostic factors. The outcomes of patients in the surgical and nonsurgical groups were compared, and Propensity Score Matching (PSM) analysis was used to reduce confounder bias. Results A total of 186 PHCT patients were identified and the median survival was 65 (95% CI [43.287, 86.713]) months. Tumor size(HR = 2.493, 95% CI[1.222,5.083], p = 0.012), male(HR = 1.690, 95% CI[1.144,2.497], p = 0.008), age(HR = 2.583, 95% CI[1.697,3.930], p < 0.001), SEER stage(HR = 1.555, 95% CI[1.184,2.044], p = 0.002) and surgery(HR = 0.292, 95% CI[0.135,0.634], p = 0.002) were significantly correlated with patient prognosis. In multivariate analysis, sex(HR = 3.206, 95% CI[1.311,7.834], p = 0.011) and surgery(HR = 0.204, 95% CI[0.043,0.966], p = 0.0045) were independent predictors of patient prognosis. Females are potentially susceptible to PHCT but have a better prognosis. With consistent baseline data, surgical patients have a better prognosis. Conclusions PHCT is uncommon and survival time is longer than that of other primary liver cancers. We found that none-surgery was potentially independent risk factors for poor prognosis.
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