期刊
CELLS
卷 10, 期 3, 页码 -出版社
MDPI
DOI: 10.3390/cells10030607
关键词
glioblastoma; cytokine; chemokine; immune suppression; microenvironment
类别
资金
- Cancer Council SA Beat Cancer Project
- Cancer Australia [GNT 1186306]
- Royal Adelaide Hospital Research Fund
- Health Services Charitable Gifts Board (HSCGB)
- Neurosurgical Research Foundation
- Hospital Research Foundation
- Australian Government Research Training Program Scholarship
Glioblastoma is the most common primary brain tumor in adults, with conventional treatments showing limited improvement in patient survival over the past decade. The immunosuppressive mechanisms employed by tumor cells can hinder treatment efficacy, highlighting the importance of understanding intercellular interactions for potential immunotherapeutic targeting and better patient outcomes.
Glioblastoma is the most common form of primary brain tumour in adults. For more than a decade, conventional treatment has produced a relatively modest improvement in the overall survival of glioblastoma patients. The immunosuppressive mechanisms employed by neoplastic and non-neoplastic cells within the tumour can limit treatment efficacy, and this can include the secretion of immunosuppressive cytokines and chemokines. These factors can play a significant role in immune modulation, thus disabling anti-tumour responses and contributing to tumour progression. Here, we review the complex interplay between populations of immune and tumour cells together with defined contributions by key cytokines and chemokines to these intercellular interactions. Understanding how these tumour-derived factors facilitate the crosstalk between cells may identify molecular candidates for potential immunotherapeutic targeting, which may enable better tumour control and improved patient survival.
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