期刊
CELLS
卷 10, 期 2, 页码 -出版社
MDPI
DOI: 10.3390/cells10020330
关键词
multiple sclerosis (MS); miRNAs; let-7; inflammation; Expanded Disability Status Scale (EDSS); progressive multiple sclerosis (PMS); RANTES; IL5; G_CSF
类别
资金
- Italian Ministry of Health [GR-2016-02361163, GR-2016-02362380, GR-2018-12366154, RF-2018-12366144]
- research fellowship FISM [2018/B/2]
- 5 per mille public funding
The study found that levels of let-7b-5p in cerebrospinal fluid of MS patients are correlated with various microRNAs and inflammation-related protein factors, showing specific expression patterns. Additionally, reduced CSF let-7b-5p levels were associated with progressive MS and negatively correlated with hallmark processes of the disease phases, indicating potential use as a biomarker for MS course.
The identification of microRNAs in biological fluids for diagnosis and prognosis is receiving great attention in the field of multiple sclerosis (MS) research but it is still in its infancy. In the present study, we observed in a large sample of MS patients that let-7b-5p levels in the cerebrospinal fluid (CSF) were highly correlated with a number of microRNAs implicated in MS, as well as with a variety of inflammation-related protein factors, showing specific expression patterns coherent with let-7b-5p-mediated regulation. Additionally, we found that the CSF let-7b-5p levels were significantly reduced in patients with the progressive MS compared to patients with relapsing-remitting MS and were negatively correlated with characteristic hallmark processes of the two phases of the disease. Indeed, in the non-progressive phase, let-7b-5p inversely associated with both central and peripheral inflammation; whereas, in progressive MS, the CSF levels of let-7b-5p negatively correlated with clinical disability at disease onset and after a follow-up period. Overall, our results uncovered, by the means of a multidisciplinary approach and multiple statistical analyses, a new possible pleiotropic action of let-7b-5p in MS, with potential utility as a biomarker of MS course.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据