Structures, Biosynthesis, and Physiological Functions of (1,3;1,4)-β-D-Glucans

(1,3;1,4)-beta-D-Glucans, also named as mixed-linkage glucans, are unbranched non-cellulosic polysaccharides containing both (1,3)- and (1,4)-beta-linkages. The linkage ratio varies depending upon species origin and has a significant impact on the physicochemical properties of the (1,3;1,4)-beta-D-glucans. (1,3;1,4)-beta-D-Glucans were thought to be unique in the grasses family (Poaceae); however, evidence has shown that (1,3;1,4)-beta-D-glucans are also synthesized in other taxa, including horsetail fern Equisetum, algae, lichens, and fungi, and more recently, bacteria. The enzyme involved in (1,3;1,4)-beta-D-glucan biosynthesis has been well studied in grasses and cereal. However, how this enzyme is able to assemble the two different linkages remains a matter of debate. Additionally, the presence of (1,3;1,4)-beta-D-glucan across the species evolutionarily distant from Poaceae but absence in some evolutionarily closely related species suggest that the synthesis is either highly conserved or has arisen twice as a result of convergent evolution. Here, we compare the structure of (1,3;1,4)-beta-D-glucans present across various taxonomic groups and provide up-to-date information on how (1,3;1,4)-beta-D-glucans are synthesized and their functions.

Automated summary

(1,3;1,4)-beta-D-Glucans, a type of polysaccharides with unique linkages, are found in various taxonomic groups. Their synthesis, evolutionary patterns, and functions remain to be fully understood and require further investigation.