期刊
JOURNAL OF CLINICAL MEDICINE
卷 10, 期 5, 页码 -出版社
MDPI
DOI: 10.3390/jcm10051144
关键词
bariatric surgery; logistic model; ALT; weight-loss
资金
- ERC StG
Comparing the effects of Sleeve Gastrectomy (SG), Roux en Y Gastric Bypass (RYGB), and One Anastomosis Gastric Bypass (OAGB) on ALT levels, the study found that SG was superior in reducing ALT levels and had a lower percentage of patients with post-surgical elevation of ALT levels compared to RYGB and OAGB.
Bariatric surgeries may lead to an improvement in metabolic fatty liver disease, and a reduction in the levels of the hepatic enzyme Alanine Aminotransferase (ALT). We compared the effects of Sleeve Gastrectomy (SG), Roux en Y Gastric Bypass (RYGB) and One Anastomosis Gastric Bypass (OAGB) on the levels of ALT by analysis of two-year follow-up data from 4980 patients in the Israeli Bariatric Registry that included laboratory tests and demographic information. Pre-operative characteristics of patients, and particularly levels of liver enzymes, were similar across surgery types. Regression modeling and retrospective matching showed that SG was superior to RYGB and OAGB in reducing ALT levels, and in reducing the fraction of patients with abnormally high ALT levels. Two-year post-surgery, an increase in ALT levels from normal to abnormal levels was observed in 5% of SG patients, and in 18% and 23% of RYGB and OAGB patients. In conclusion, SG leads to a greater reduction in ALT levels compared with bypass surgeries and a lower incidence of post-surgical elevation of ALT levels. Further studies are required to identify the cause for the rise in liver enzymes, and to determine whether ALT levels correlate with liver pathology especially following bariatric surgery.
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