Staphylococcus aureus Keratitis: Incidence, Pathophysiology, Risk Factors and Novel Strategies for Treatment

Bacterial keratitis is a devastating condition that can rapidly progress to serious complications if not treated promptly. Certain causative microorganisms such as Staphylococcus aureus and Pseudomonas aeruginosa are notorious for their resistance to antibiotics. Resistant bacterial keratitis results in poorer outcomes such as scarring and the need for surgical intervention. Thorough understanding of the causative pathogen and its virulence factors is vital for the discovery of novel treatments to avoid further antibiotic resistance. While much has been previously reported on P. aeruginosa, S. aureus has been less extensively studied. This review aims to give a brief overview of S. aureus epidemiology, pathophysiology and clinical characteristics as well as summarise the current evidence for potential novel therapies.

Automated summary

Bacterial keratitis, especially caused by antibiotic-resistant microorganisms like Staphylococcus aureus and Pseudomonas aeruginosa, can lead to severe complications if not treated promptly. Understanding the causative pathogen and its virulence factors is crucial for discovering novel treatments and avoiding further antibiotic resistance. While P. aeruginosa has been extensively studied, there is a need for more research on S. aureus to explore potential novel therapies.