期刊
JOURNAL OF CLINICAL MEDICINE
卷 10, 期 4, 页码 -出版社
MDPI
DOI: 10.3390/jcm10040792
关键词
ceramide; liver; NAFLD; NASH; sphingolipids; steatosis
资金
- Agence Nationale de la Recherche [SONIC ANR-18CE17-0022-01]
- Institut Hospitalo-Universitaire ICAN
- Federation Francaise de Recherche sur le Diabete
- Fondation de France
Non-alcoholic fatty liver disease is a common chronic liver disease, with increasing prevalence in Western countries due to the obesity epidemic. Liver fat accumulation and the synthesis of specific lipid species, particularly ceramides, have deleterious effects on hepatic metabolism, a phenomenon known as lipotoxicity.
Non-alcoholic fatty liver disease is one of the most common chronic liver diseases, ranging from simple steatosis to steatohepatitis, fibrosis, and cirrhosis. Its prevalence is rapidly increasing and presently affects around 25% of the general population of Western countries, due to the obesity epidemic. Liver fat accumulation induces the synthesis of specific lipid species and particularly ceramides, a sphingolipid. In turn, ceramides have deleterious effects on hepatic metabolism, a phenomenon called lipotoxicity. We review here the evidence showing the role of ceramides in non-alcoholic fatty liver disease and the mechanisms underlying their effects.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据