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Primary Immune Thrombocytopenia: Novel Insights into Pathophysiology and Disease Management

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Summary: In this study, novel effector functions of autoantibodies in patients with immune thrombocytopenia were identified, which interfere with the clinical presentation of the disease by inducing cleavage of sialic acid residues from the surface of platelets and megakaryocytes. Additionally, desialylation mediated by autoantibodies disrupts the interaction between cells and extracellular matrix proteins, leading to impaired platelet adhesion and megakaryocyte differentiation. This suggests that prevention of desialylation may be a potential therapeutic approach in the future clinical studies for treating bleeding in immune thrombocytopenia.

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