期刊
JOURNAL OF CLINICAL MEDICINE
卷 10, 期 3, 页码 -出版社
MDPI
DOI: 10.3390/jcm10030480
关键词
β -lactolin; cerebral blood flow; dorsolateral prefrontal cortex; near-infrared spectroscopy; whey; working memory
资金
- Kirin Holdings Company, Ltd.
This study found that beta-lactolin supplementation increases regional cerebral blood flow (rCBF) and dorsolateral prefrontal cortex (DLPFC) activity during working memory tasks in humans.
Epidemiological studies have reported that consumption of dairy products rich in beta-lactolin is beneficial for cognitive decline among elderly individuals. Although previous studies have shown that beta-lactolin supplementation improves memory function and attention in healthy adults, the mechanism through which beta-lactolin affects human brain function has yet to be elucidated. This placebo-controlled randomized double-blind study therefore examined the effects of beta-lactolin on human regional cerebral blood flow (rCBF) using near-infrared spectroscopy (NIRS) according to the Consolidated Standards of Reporting Trials guidelines. A total of 114 healthy participants aged between 50 and 75 years with relatively low cognition were randomly allocated into the beta-lactolin or placebo groups (n = 57 for both groups) and received supplementation for 6 weeks. After the 6 weeks of supplementation, total hemoglobin during cognitive tasks (Kraepelin and 2-back tasks) was measured using two-channel NIRS to determine rCBF. Accordingly, the beta-lactolin group had significantly higher changes in total hemoglobin at the left dorsolateral prefrontal cortex (DLPFC) area measured using the left-side channel during the 2-back tasks (p = 0.027) compared to the placebo group. The present study suggests that beta-lactolin supplementation increases rCBF and DLPFC activity during working memory tasks.
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