期刊
JOURNAL OF CLINICAL MEDICINE
卷 10, 期 5, 页码 -出版社
MDPI
DOI: 10.3390/jcm10051137
关键词
C-reactive protein; MCP-1; NT-proBNP; inflammation
资金
- Fondo de Investigaciones Sanitarias [PI14/1567, PI05/0451, PI16/01419, PI17/01615, PI17/01495, PI19/00128]
- RETOS-Colaboracion [RTC2019-006826-1]
- Spanish Society of Arteriosclerosis
- Instituto de Salud Carlos III FEDER [RD09/0076/00101]
The study found that MCP-1 plasma concentration is associated with recurrent cardiovascular events in patients with persistent inflammation, while NT-proBNP and MCP-1 are not associated with primary outcome in patients with low inflammation.
Clinical data indicate that patients with C-reactive protein (CRP) levels higher than 2 mg per liter suffer from persistent inflammation, which is associated with high risk of cardiovascular disease (CVD). We determined whether a panel of biomarkers associated with CVD could predict recurrent events in patients with low or persistent inflammation and coronary artery disease (CAD). We followed 917 patients with CAD (median 4.59 +/- 2.39 years), assessing CRP, galectin-3, monocyte chemoattractant protein-1 (MCP-1), N-terminal fragment of brain natriuretic peptide (NT-proBNP) and troponin-I plasma levels. The primary outcome was the combination of cardiovascular events (acute coronary syndrome, stroke or transient ischemic event, heart failure or death). Patients with persistent inflammation (n = 343) showed higher NT-proBNP and MCP-1 plasma levels compared to patients with CRP < 2 mg/L. Neither MCP-1 nor NT-proBNP was associated with primary outcome in patients with CRP < 2 mg/L. However, NT-proBNP and MCP-1 plasma levels were associated with increased risk of the primary outcome in patients with persistent inflammation. When patients were divided by type of event, MCP-1 was associated with an increased risk of acute ischemic events. A significant interaction between MCP-1 and persistent inflammation was found (synergy index: 6.17 (4.39-7.95)). In conclusion, MCP-1 plasma concentration is associated with recurrent cardiovascular events in patients with persistent inflammation.
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