期刊
JOURNAL OF CLINICAL MEDICINE
卷 10, 期 4, 页码 -出版社
MDPI
DOI: 10.3390/jcm10040893
关键词
osteosarcoma; cold atmospheric plasma; plasma treated liquids; reactive oxygen and nitrogen species; oxidative stress; tumor microenvironment; cancer stem cells
资金
- European Research Council (ERC) under the European Union's Horizon 2020 research and innovation program [714793]
This review discusses the current status of cold plasma therapy for osteosarcoma, emphasizing the mechanisms of action of plasmas on this type of bone tumor. The main challenge for the future development of osteosarcoma therapies based on cold plasma lies in overcoming critical barriers to progress in this emerging technique.
Osteosarcoma is the most common primary bone tumor, and its first line of treatment presents a high failure rate. The 5-year survival for children and teenagers with osteosarcoma is 70% (if diagnosed before it has metastasized) or 20% (if spread at the time of diagnosis), stressing the need for novel therapies. Recently, cold atmospheric plasmas (ionized gases consisting of UV-Vis radiation, electromagnetic fields and a great variety of reactive species) and plasma-treated liquids have been shown to have the potential to selectively eliminate cancer cells in different tumors through an oxidative stress-dependent mechanism. In this work, we review the current state of the art in cold plasma therapy for osteosarcoma. Specifically, we emphasize the mechanisms unveiled thus far regarding the action of plasmas on osteosarcoma. Finally, we review current and potential future approaches, emphasizing the most critical challenges for the development of osteosarcoma therapies based on this emerging technique.
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