期刊
EBIOMEDICINE
卷 65, 期 -, 页码 -出版社
ELSEVIER
DOI: 10.1016/j.ebiom.2021.103260
关键词
Genetics; Africa; Cancer; Diabetes; Hypertension; Obesity
资金
- Wellcome Trust [214205/Z/18/Z, 107743]
- Wellcome Trust grant at the MRC/UVRI [220740/Z/20/Z]
- LSHTM
- NIH [U01MH115485]
- Makerere University-Uganda Virus Research Institute Centre of Excellence for Infection and Immunity Research and Training (MUII)
- DELTAS Africa Initiative [107743]
- African Academy of Sciences (AAS)
- Alliance for Accelerating Excellence in Science in Africa (AESA)
- New Partnership for Africa\220s Development Planning and Coordinating Agency (NEPAD Agency)
- U.K. government
- Department of Medicine, University of Cape Town (under the Mayosi research group's RHDGen Fellowship (Wellcome Trust, H3Africa project)) [099313/B/12/A]
- UCT Crasnow Travel Scholarship
- Population Health Research Institute (PHRI)
- McMaster University through the inaugural Bongani Mayosi UCT-PHRI Scholarship 2019/2020
- Wellcome Trust [099313/B/12/A, 220740/Z/20/Z] Funding Source: Wellcome Trust
Non-communicable diseases are a major cause of death globally, with Africa facing a potentially higher burden in the future. Despite lagging behind in genetic research, Africa shows promise in applying precision medicine through emerging genomic research initiatives.
Non-communicable diseases (NCDs) kill more than 41 million people every year, accounting for 71% of all deaths globally. The prevalence of NCDs is estimated to be higher than that of infectious diseases in Africa by 2030. Precision medicine may help with early identification of cases, resulting in timely prevention and improvement in the efficacy of treatments. However, Africa has been lagging behind in genetic research, a key component of the precision medicine initiative. A number of genomic research initiatives which could lead to translational genomics are emerging on the African continent which includes the Non-communicable Diseases Genetic Heritage Study (NCDGHS) and the Men of African Descent and Carcinoma of the Prostate (MADCaP) Network. These offer a promise that precision medicine can be applied in African countries. This review evaluates the advances of genetic studies for cancer, hypertension, type 2 diabetes and body mass index (BMI) in Africa. (C) 2021 The Author(s). Published by Elsevier B.V.
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