4.8 Article

Wireless, implantable catheter-type oximeter designed for cardiac oxygen saturation

期刊

SCIENCE ADVANCES
卷 7, 期 7, 页码 -

出版社

AMER ASSOC ADVANCEMENT SCIENCE
DOI: 10.1126/sciadv.abe0579

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资金

  1. Center for Bio-Integrated Electronics at Northwestern University
  2. National Natural Science Foundation of China [12072057, 21974079]
  3. Fundamental Research Funds for the Central Universities [DUT20RC(3)032]
  4. City University of Hong Kong [9610423]
  5. NSF [CMMI1635443]
  6. National Science Foundation Graduate Research Fellowship (NSF) [DGE-1842165]
  7. Ford Foundation Predoctoral Fellowship
  8. Querrey Simpson Institute for Bioelectronics

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The wireless, miniaturized, implantable optoelectronic catheter system introduced in this report offers high performance and patient-friendly monitoring of cardiopulmonary health, avoiding the risks and limitations associated with traditional technologies. In vitro and in vivo testing shows equivalent measurement accuracy and precision to existing clinical standards.
Accurate, real-time monitoring of intravascular oxygen levels is important in tracking the cardiopulmonary health of patients after cardiothoracic surgery. Existing technologies use intravascular placement of glass fiber-optic catheters that pose risks of blood vessel damage, thrombosis, and infection. In addition, physical tethers to power supply systems and data acquisition hardware limit freedom of movement and add clutter to the intensive care unit. This report introduces a wireless, miniaturized, implantable optoelectronic catheter system incorporating optical components on the probe, encapsulated by soft biocompatible materials, as alternative technology that avoids these disadvantages. The absence of physical tethers and the flexible, biocompatible construction of the probe represent key defining features, resulting in a high-performance, patient-friendly implantable oximeter that can monitor localized tissue oxygenation, heart rate, and respiratory activity with wireless, real-time, continuous operation. In vitro and in vivo testing shows that this platform offers measurement accuracy and precision equivalent to those of existing clinical standards.

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