期刊
SCIENCE ADVANCES
卷 7, 期 9, 页码 -出版社
AMER ASSOC ADVANCEMENT SCIENCE
DOI: 10.1126/sciadv.abd9421
关键词
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资金
- Spanish State Research Agency
- European Regional Development Fund
- Spanish Ministry of Economy, Industry, and Competitiveness [BFU2013-41249-P, BIO2015-68990-REDT]
- Agencia Estatal CSIC [2019AEP045]
- Severo Ochoa Excellence grant [SEV 2017-0712]
- Natural Sciences and Engineering Research Council of Canada [194562-08]
- Juan de la Cierva postdoctoral contract - Spanish State Research Agency
- La Caixa Foundation [100010434, LCF/BQ/SO16/52270032]
- iNEXT - Horizon 2020 Programme of the European Union [653706]
- MEYS CR [LM2018127]
- [PID2019-104098GB-I00/AEI/10.13039/501100011033]
- [BFU2016-74868-P]
Enteric adenovirus HAdV-F41 has unique capsid stability compared to other adenoviruses, with partially ordered elements reinforcing its stability. Additionally, the organization of its external minor coat protein IX differs from all previously characterized human and nonhuman mastadenoviruses, providing valuable insights for the development of vectors suitable for oral delivery or intestinal targeting.
Enteric adenoviruses, one of the main causes of viral gastroenteritis in the world, must withstand the harsh conditions found in the gut. This requirement suggests that capsid stability must be different from that of other adenoviruses. We report the 4-angstrom-resolution structure of a human enteric adenovirus, HAdV-F41, and compare it with that of other adenoviruses with respiratory (HAdV-C5) and ocular (HAdV-D26) tropisms. While the overall structures of hexon, penton base, and internal minor coat proteins IIIa and VIII are conserved, we observe partially ordered elements reinforcing the vertex region, which suggests their role in enhancing the physicochemical capsid stability of HAdV-F41. Unexpectedly, we find an organization of the external minor coat protein IX different from all previously characterized human and nonhuman mastadenoviruses. Knowledge of the structure of enteric adenoviruses provides a starting point for the design of vectors suitable for oral delivery or intestinal targeting.
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