Controlling Radical Relay Processes with Visible Light

Harnessing free radical intermediates for selective functionalization of organic compounds has been widely demonstrated under photocatalytic conditions requiring a distinct photocatalyst. In this issue of Chem, Seo, Chang, and co-workers demonstrate an alternative photocatalyst- free light-mediated approach that allows efficient amidation of aldehydes via N-centered radical intermediate.

Automated summary

The authors present an innovative approach for amidation of aldehydes via N-centered radical intermediates without the need for a photocatalyst.