Photoinduced Activation of Unactivated C(sp3)-H Bonds and Acylation Reactions

An efficient and benign method of C (sp(3))-H acylation based on the direct conversion of stable amides has been established. This photoredox cross-coupling of amides and methylbenzenes for aromatic ketones is enabled by the cheap benzophenone photocatalyst and nickel catalyst, with high yield (up to 90 %). The benzophenone catalyst having electron-withdrawing group promotes the efficiency of hydrogen atom transfer, which is beneficial to improve the yield.

Automated summary

An efficient and mild C(sp(3))-H acylation method has been developed based on the direct conversion of stable amides. This photoredox cross-coupling of amides and methylbenzenes for aromatic ketones is enabled by cheap benzophenone photocatalyst and nickel catalyst, achieving high yields (up to 90%). The benzophenone catalyst with electron-withdrawing groups promotes hydrogen atom transfer efficiency, contributing to increased yields.