One-pot Suzuki Coupling-Knoevenagel Condensation Tandem Reaction Catalyzed by a Recyclable Magnetic Bifunctional Catalyst

A novel magnetic nanoparticle-supported bifunctional catalyst NH-Pd(0)@MNP was prepared and its activity was evaluated in one-pot Suzuki coupling-Knoevenagel condensation tandem reaction. A series of biaryl derivatives were synthesized via sequential Suzuki coupling-Knoevenagel condensation in ethanol/water medium under phosphine-free conditions. Meanwhile, the catalyst could be easily separated by an external magnetic field, and could be reused several times without remarkable loss of catalytic activity.

Automated summary

The novel magnetic nanoparticle-supported bifunctional catalyst NH-Pd(0)@MNP was successfully prepared and evaluated in a one-pot tandem reaction, producing a series of biaryl derivatives under phosphine-free conditions. The catalyst can be easily separated using an external magnetic field and reused multiple times without significant loss of catalytic activity.