Advances in Retinal Oximetry

Similar to other organs, the retina relies on tightly regulated perfusion and oxygenation. Previous studies have demonstrated that retinal blood flow is affected in a variety of eye and systemic diseases, including diabetic retinopathy, age-related macular degeneration, and glaucoma. Although measurement of peripheral oxygen saturation has become a standard clinical measurement through the development of pulse oximetry, developing a noninvasive technique to measure retinal oxygen saturation has proven challenging, and retinal oximetry technology currently remains inadequate for reliable clinical use. Here, we review current strategies and approaches, as well as several newer technologies in development, and discuss the future of retinal oximetry.

Automated summary

Similar to other organs, the retina relies on tightly regulated perfusion and oxygenation, and various eye and systemic diseases have been shown to affect retinal blood flow. While peripheral oxygen saturation measurement has become a standard clinical measurement, developing a noninvasive technique to measure retinal oxygen saturation remains challenging. Current retinal oximetry technology is inadequate for reliable clinical use, but newer technologies and approaches are being developed for the future.