期刊
ROYAL SOCIETY OPEN SCIENCE
卷 8, 期 3, 页码 -出版社
ROYAL SOC
DOI: 10.1098/rsos.202148
关键词
carbonated hydroxyapatite; microspheres; controllable size; EDTA
资金
- National Natural Science Foundation of China [11947117, 12004227, 51803109]
- Natural Science Foundation of Shandong Province [ZR2020QE070, ZR2020QA076]
- China Postdoctoral Science Foundation [2019M660164]
This study successfully synthesized flowerlike carbonated HA microspheres via a one-step hydrothermal route, demonstrating that the particle size of the microspheres can be controlled by adjusting the EDTA concentration. The mechanism of morphological transition of the microspheres under hydrothermal conditions with different EDTA concentrations was proposed.
Ethylenediamine tetraacetic acid (EDTA) is considered an effective crystal growth modifier for template-assisted hydrothermal synthesis of hydroxyapatite (HA) materials. In this work, flowerlike-carbonated HA (CHA) microspheres were synthesized using EDTA via a one-step hydrothermal route. The phase, functional groups, morphology and particle size distribution of the products were examined by X-ray diffraction, Fourier transform infrared spectrometer, field emission scanning electron microscopy as well as laser diffraction particle size analysis. Results show that the morphology of the products can be well controlled by adjusting the EDTA concentration. With an increase of the EDTA concentration, the particle size of flowerlike microspheres decreased from tens of microns down to a few microns. The underlying mechanism for the morphological transition of CHA microspheres with different concentrations of EDTA under hydrothermal conditions is proposed. This work provides a simple way to controllably fabricate CHA microspheres with various sizes using the same synthesis system for biomedical applications, such as cell carriers and drug delivery.
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