期刊
APPLIED NANOSCIENCE
卷 -, 期 -, 页码 -出版社
SPRINGER HEIDELBERG
DOI: 10.1007/s13204-021-01735-5
关键词
Micromotors; Catalytic motors; Cancer; Cancer cell; miRNA-21; Intracellular environment
资金
- Scientific and Technological Research Council of Turkey [1150098]
The study focused on the preparation and characterization of catalytic gold/poly(3,4-ethylenedioxythiophene)/platinum micromotors for cancer biomarker miRNA-21 detection, and also explored their potential use in cancer treatment. Intracellular studies demonstrated the high selectivity of the micromotors for specific cancer cells, highlighting their potential in targeted cancer therapy.
The synthesis and biomedical applications of nano/micromotors have attracted great attention. In this work, preparation and characterization of catalytic gold/poly(3,4-ethylenedioxythiophene)/platinum (Au/PEDOT/Pt) micromotors were reported to present their contribution for cancer biomarker miRNA-21 detection. Potential use of these motors for possible cancer treatment was also illustrated after their biocompability had shown. At first, anti-miRNA probe immobilized Au/PEDOT/Pt micromotors (probe DNA/Au/PEDOT/Pt/MMs) were used for the sensitive and selective recognition of synthetic miRNA-21 target sequence to present the proof-of-concept. Then intracellular studies were carried out using four types of cancer cells (human breast cancer cell line, MCF-7, human colorectal adenocarcinoma cell line, HT-29, human lung carcinoma cell line, A-549 and human osteosarcoma cell line, SJSA-1). These studies illustrated the high selectivity of probe DNA/Au/PEDOT/Pt micromotors for MCF-7 and SJSA-1 cells. Later, antiproliferative and cytotoxic effects of the micromotors and their potential use for breast cancer treatment were investigated.
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