期刊
FRONTIERS IN PSYCHIATRY
卷 12, 期 -, 页码 -出版社
FRONTIERS MEDIA SA
DOI: 10.3389/fpsyt.2021.644161
关键词
social stress; female; mouse; sex difference; repeated social defeat stress model (RSDS)
类别
资金
- JSPS KAKENHI [JP17H04766, JP19H05202]
- Adaptable and Seamless Technology transfer Program through Target-driven R&D (A-STEP) from Japan Science and Technology Agency (JST) [JPMJTM20BW]
Significant sex differences exist in psychiatric disorders, with women being more vulnerable to stress-related disorders such as depression and anxiety. Recent research has focused on female mice in the study of repeated social defeat stress models, highlighting the importance of considering various factors in using this model.
Significant sex differences in terms of prevalence, symptomatic profiles, severity, and comorbidities of psychiatric disorders are quite common. Women have been shown to be more vulnerable to stress and are nearly twice as likely as men to develop stress-related disorders such as depression and anxiety. Therefore, understanding sex differences with respect to the neurobiological mechanisms underlying stress-related disorders is important for developing more efficient pharmacological interventions for women. However, most preclinical studies on stress-related disorders have focused heavily on male rodents. Here, recent developments in the study of repeated social defeat stress models in female mice are summarized. Our findings suggest that a variety of factors need to be considered when employing this model.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据