The Function of the Metals in Regulating Epigenetics During Parkinson's Disease

Parkinson's means Parkinson's disease, a chronic degenerative disease of central nervous system. The main area which is affected by this disease is motor system. Since it firstly founded by James Parkinson in his 1817 publication, nowadays, people still have lots of questions about this disease. This review mainly summarizes the epigenetics of Parkinson's. DNA methylation is one of the epigenetic mechanisms of Parkinson's. During the development of disease, global hypomethylation, and hypermethylation happen in different areas of patients. Another epigenetic mechanism is histone modification. People believe that some metals can induce Parkinson's disease by modulating epigenetic mechanisms. This review summarizes the relationships between different metals and Parkinson's disease. However, the specific roles of most metals in epigenetics are still unknown, which need further research.

Automated summary

Parkinson's disease is a chronic degenerative disease of the central nervous system, mainly affecting the motor system. Studies have shown that Parkinson's disease involves epigenetic mechanisms such as DNA methylation and histone modification. Some metals may induce Parkinson's disease by modulating epigenetic mechanisms, but the specific roles of most metals in this aspect are still unknown and require further research.