Recent Advances in the Direct Electron Transfer-Enabled Enzymatic Fuel Cells

Direct electron transfer (DET), which requires no mediator to shuttle electrons from enzyme active site to the electrode surface, minimizes complexity caused by the mediator and can further enable miniaturization for biocompatible and implantable devices. However, because the redox cofactors are typically deeply embedded in the protein matrix of the enzymes, electrons generated from oxidation reaction cannot easily transfer to the electrode surface. In this review, methods to improve the DET rate for enhancement of enzymatic fuel cell performances are summarized, with a focus on the more recent works (past 10 years). Finally, progress on the application of DET-enabled EFC to some biomedical and implantable devices are reported.

Automated summary

This review summarizes methods to improve the DET rate for enhancing enzymatic fuel cell performances, focusing on more recent works in the past 10 years. Progress on the application of DET-enabled EFC to some biomedical and implantable devices is also reported.