期刊
ARAB JOURNAL OF GASTROENTEROLOGY
卷 22, 期 1, 页码 12-22出版社
ELSEVIER
DOI: 10.1016/j.ajg.2020.09.004
关键词
Hepatocellular carcinoma; Surgical resection; Alpha-fetoproteins; Prognosis
This study conducted a meta-analysis to assess the relationship between alpha-fetoprotein (AFP) levels and the prognosis of hepatocellular carcinoma (HCC) after surgical resection. The results showed that elevated serum AFP levels are associated with poor prognosis of HCC.
Background and study aims: The relationship between the alpha-fetoprotein (AFP) level and the prognosis of hepatocellular carcinoma (HCC) after surgical resection remains unknown. This study aims to assess this relationship. Patients and methods: PubMed and Web of Science were systematically utilised. Meta-analysis was conducted for the outcomes of the recurrence-free survival (RFS) and the overall survival (OS) by comparing the high AFP group with the low AFP group. Results: The studies included 61 manuscripts with 35,461 patients. The summary hazard ratio (HR) for RFS was 1.501 (95% CI 1.355-1.662; Z = 7.81, P < 0.00001) when comparing the high AFP group with the low AFP group. Sensitivity analysis only included adjusted HRs, with the summary HR being 1.563 (95% CI 1.381-1.768; Z = 7.10, P < 0.00001). The summary HR for OS was 1.565 (95% CI 1.439-1.701; Z = 10.52, P < 0.00001) when comparing two AFP groups. Sensitivity analysis showed that the summary HR was 1.611 (95% CI 1.456-1.782; Z = 9.24, P < 0.00001). Conclusion: Our meta-analysis indicated that elevated serum AFP levels are associated with poor prognosis of HCC after surgical resection. (C) 2020 Pan-Arab Association of Gastroenterology. Published by Elsevier B.V. All rights reserved.
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