A Case Report of Central Nervous System Graft-Versus-Host Disease and Literature Review

As an adverse immune phenomenon, graft-versus-host disease often occurs after allogeneic hematopoietic stem cell transplantation. The incidence of acute and chronic graft-versus-host disease is about 40-60% and the mortality rate can reach 15%, which is a potentially fatal disease. There are rare GvHD cases involving the central nervous system. We reported a rare case of diffuse white matter changes after haploid bone marrow transplantation, summarizing its clinical manifestations and diagnosis and treatment in conjunction with the literature.

Automated summary

Graft-versus-host disease, an adverse immune phenomenon occurring after allogeneic hematopoietic stem cell transplantation, has a high incidence rate with potential fatal consequences. Rare cases involving the central nervous system have been reported, highlighting the importance of clinical manifestations and literature in the diagnosis and treatment of this disease.