4.6 Article

Seizure Clusters, Seizure Severity Markers, and SUDEP Risk

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Association of Peri-ictal Brainstem Posturing With Seizure Severity and Breathing Compromise in Patients With Generalized Convulsive Seizures

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Summary: The study found that peri-ictal brainstem posturing is associated with increased risk of postictal generalized electroencephalographic suppression (PGES) and breathing dysfunction in generalized convulsive seizures (GCS). Specifically, ictal decerebration was linked to longer PGES, and postictal posturing was associated with postconvulsive central apnea, longer hypoxemia, and SpO(2) recovery. This suggests that peri-ictal brainstem posturing may be a useful biomarker for GCS severity.

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