Hyperventilation in Adult TBI Patients: How to Approach It?

Hyperventilation is a commonly used therapy to treat intracranial hypertension (ICTH) in traumatic brain injury patients (TBI). Hyperventilation promotes hypocapnia, which causes vasoconstriction in the cerebral arterioles and thus reduces cerebral blood flow and, to a lesser extent, cerebral blood volume effectively, decreasing temporarily intracranial pressure. However, hyperventilation can have serious systemic and cerebral deleterious effects, such as ventilator-induced lung injury or cerebral ischemia. The routine use of this therapy is therefore not recommended. Conversely, in specific conditions, such as refractory ICHT and imminent brain herniation, it can be an effective life-saving rescue therapy. The aim of this review is to describe the impact of hyperventilation on extra-cerebral organs and cerebral hemodynamics or metabolism, as well as to discuss the side effects and how to implement it to manage TBI patients.

Automated summary

Hyperventilation is a commonly used therapy for intracranial hypertension in traumatic brain injury patients, by promoting hypocapnia to reduce cerebral blood flow and volume temporarily. However, it can have serious systemic and cerebral deleterious effects, so routine use is not recommended. In specific conditions like refractory ICHT, it can be an effective life-saving rescue therapy.