期刊
FRONTIERS IN IMMUNOLOGY
卷 12, 期 -, 页码 -出版社
FRONTIERS MEDIA SA
DOI: 10.3389/fimmu.2021.641507
关键词
RNA methylation; M6A; immunoregulation; tumor immunity; immunotherapy
类别
资金
- National Natural Science Foundation of China [81972663, 81560385]
- Key Scientific Research Projects of Institutions of Higher Education in Henan Province [19A310024]
- Medical Scientific and Technological Research Project of Henan Province [201702027]
- Youth Innovation Fund Project of The First Affiliated Hospital of Zhengzhou University [YNQN2017035]
- China Postdoctoral Science Foundation [2019T120648, 2017M610462]
- National Natural Science Foundation of Henan Province [182300410342]
- Health Commission Technology Talents Overseas Training Project of Henan Province [2018140]
RNA methylation is a widely existing RNA modification in eukaryotes and prokaryotes, affecting various aspects of RNA such as splicing, nucleation, stability, and immunogenicity. It plays a role in many physiological and pathological processes, particularly in the immune system. Through regulating RNA immunogenicity and innate immune components, RNA methylation influences the innate immunity of the body.
RNA methylation is a kind of RNA modification that exists widely in eukaryotes and prokaryotes. RNA methylation occurs not only in mRNA but also in ncRNA. According to the different sites of methylation, RNA methylation includes m(6)A, m(5)C, m(7)G, and 2-O-methylation modifications. Modifications affect the splicing, nucleation, stability and immunogenicity of RNA. RNA methylation is involved in many physiological and pathological processes. In the immune system, especially for tumor immunity, RNA methylation affects the maturation and response function of immune cells. Through the influence of RNA immunogenicity and innate immune components, modifications regulate the innate immunity of the body. Some recent studies verified that RNA methylation can regulate tumor immunity, which also provides a new idea for the future of treating immunological diseases and tumor immunotherapy.
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