期刊
FRONTIERS IN IMMUNOLOGY
卷 11, 期 -, 页码 -出版社
FRONTIERS MEDIA SA
DOI: 10.3389/fimmu.2020.607945
关键词
phagocytosis; F-actin (filamentous actin); pathogens; vaccination; endocytosis
类别
资金
- Human Frontier Science Program (HFSP) [RGY0080/2018]
- European Research Council (ERC) under the European Union's Horizon 2020 research and innovation program [862137]
- Netherlands Organization for Scientific Research (Vidi grant) [NWO-ALW VIDI 864.14.001]
- Department of Atomic Energy, Government of India [12-RD-TFR-5.04-0800, 12-DD-TFR-5.10-1100]
- Simons Foundation [287975]
- Max Planck Society through a Max-Planck Partner-Group
The size, shape, rigidity, and surface roughness of pathogens are important parameters affecting cellular uptake and immune responses, particularly in inflammasome activation and T cell activation. Understanding how the physical properties of particles influence immune responses can assist in the design of more effective vaccines.
The immune system has to cope with a wide range of irregularly shaped pathogens that can actively move (e.g., by flagella) and also dynamically remodel their shape (e.g., transition from yeast-shaped to hyphal fungi). The goal of this review is to draw general conclusions of how the size and geometry of a pathogen affect its uptake and processing by phagocytes of the immune system. We compared both theoretical and experimental studies with different cells, model particles, and pathogenic microbes (particularly fungi) showing that particle size, shape, rigidity, and surface roughness are important parameters for cellular uptake and subsequent immune responses, particularly inflammasome activation and T cell activation. Understanding how the physical properties of particles affect immune responses can aid the design of better vaccines.
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