4.8 Article

Systems Biology Analysis of the Radiation-Attenuated Schistosome Vaccine Reveals a Role for Growth Factors in Protection and Hemostasis Inhibition in Parasite Survival

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Summary: The study utilized radiation-attenuated cercarial vaccine to induce protective immunity against Schistosoma mansoni and identified likely epitopes that mediate the protection. By screening peptide arrays, prioritizing vaccine over infection serum, 44 priority peptides from proteins were identified for further investigation in multiepitope vaccine constructs and as targets of monoclonal antibodies.

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