期刊
FRONTIERS IN IMMUNOLOGY
卷 12, 期 -, 页码 -出版社
FRONTIERS MEDIA SA
DOI: 10.3389/fimmu.2021.626235
关键词
soluble interleukin 2 receptor; interleukin 8; interleukin 6; neutrophil-to-lymphocytes ratio; severe acute respiratory syndrome coronavirus− 2; coronavirus disease 2019
类别
资金
- National Natural Science Foundation of China [81600048]
- Xiamen Science and Technology Bureau [3502Z20194004]
- Deutsche Forschungsgemeinschaft [DFG-27260646, GRK1727]
- German Center for Lung Research (DZL)
The study found a positive association between the duration of illness in patients with severe COVID-19 and serum levels of IL-8 and soluble IL-2R alpha, indicating the involvement of neutrophils and T cells in the evolution of COVID-19.
Objectives The coordinated immune response of the host is the key of the successful combat of the body against SARS-CoV-2 infection and is decisive for the development and progression of COVID-19. In this study, we aimed to investigate whether the immunological phenotype of patients are associated with duration of illness in patients with severe COVID-19. Method In this single-center study, 69 patients with severe or critical COVID-19 were recruited retrospectively. Immunological parameters including counts of white blood cells, neutrophils, lymphocytes, the neutrophil-to-lymphocyte ratio, and levels of circulating cytokines and cytokine receptors were screened for their association with disease severity, survival and duration of illness of COVID-19. Results Our data confirmed previous results that neutrophil-to-lymphocyte ratio and circulating levels of IL-6 represent prominent biomarker for the prediction of disease severity and survival of COVID-19. However, this study shows for the first time that duration of illness in patients with severe COVID-19 is positively associated with serum levels of IL-8 (P=0.004) and soluble IL-2R alpha (P=0.025). Conclusion The significant association of duration of illness with circulating levels of IL-8 and soluble IL-2R alpha in patients with severe COVID-19 implicates that neutrophils and T cells are involved in the evolution of COVID-19.
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