CD8+ T Lymphocytes: Crucial Players in Sjogren's Syndrome

Primary Sjogren's syndrome (pSS) is a chronic autoimmune disease associated with damage to multiple organs and glands. The most common clinical manifestations are dry eyes, dry mouth, and enlarged salivary glands. Currently, CD4(+) T lymphocytes are considered to be key factors in the immunopathogenesis of pSS, but various studies have shown that CD8(+) T lymphocytes contribute to acinar injury in the exocrine glands. Therefore, in this review, we discussed the classification and features of CD8(+) T lymphocytes, specifically describing the role of CD8(+) T lymphocytes in disease pathophysiology. Furthermore, we presented treatment strategies targeting CD8(+) T cells to capitalize on the pathogenic and regulatory potential of CD8(+) T lymphocytes in SS to provide promising new strategies for this inflammatory disease.

Automated summary

Primary Sjogren's syndrome (pSS) is a chronic autoimmune disease characterized by damage to multiple organs and glands, with dry eyes, dry mouth, and enlarged salivary glands being common clinical manifestations. CD8(+) T lymphocytes have been found to play a significant role in acinar injury in the exocrine glands, contributing to the pathophysiology of the disease. Targeting CD8(+) T cells in treatment strategies can offer promising new approaches for managing pSS.