期刊
FRONTIERS IN IMMUNOLOGY
卷 12, 期 -, 页码 -出版社
FRONTIERS MEDIA SA
DOI: 10.3389/fimmu.2021.603563
关键词
interferon gamma; T cells; neutralization antibody; adaptive immunity; acute respiratory distress syndrome; SARS-CoV-2
类别
资金
- National Key Research and Development Program of China [2016YFC1303900]
- Tsinghua University Spring Breeze Fund [2020Z99CFG008]
- Natural Science Foundation of China [31991173, 31821003, 31991170]
- Beijing Municipal Science and Technology [Z181100001318007, Z181100006318015, Z171100000417005]
- Zhejiang University Foundation [2020XGZX014]
- Science and Technology Development Plan Project of Jilin Province [20200901007SF]
- Science and Technology Plan of Beijing Chaoyang District [CYSF2061]
- Beijing Hospital Authority [DFL20191801]
Severe COVID-19 patients with acute respiratory distress syndrome (ARDS) showed specific antibody responses to SARS-CoV-2, but had reduced levels of NK cells and CD8(+) T cells, as well as decreased IFN gamma expression in CD4(+) T cells. Their lymphocytes in peripheral blood failed to produce IFN gamma against viral proteins, highlighting the importance of cellular immunity in COVID-19.
The high infection rate and rapid spread of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) make it a world-wide pandemic. Individuals infected by the virus exhibited different degrees of symptoms, and most convalescent individuals have been shown to develop both cellular and humoral immune responses. However, virus-specific adaptive immune responses in severe patients during acute phase have not been thoroughly studied. Here, we found that in a group of COVID-19 patients with acute respiratory distress syndrome (ARDS) during hospitalization, most of them mounted SARS-CoV-2-specific antibody responses, including neutralizing antibodies. However, compared to healthy controls, the percentages and absolute numbers of both NK cells and CD8(+) T cells were significantly reduced, with decreased IFN gamma expression in CD4(+) T cells in peripheral blood from severe patients. Most notably, their peripheral blood lymphocytes failed in producing IFN gamma against viral proteins. Thus, severe COVID-19 patients at acute infection stage developed SARS-CoV-2-specific antibody responses but were impaired in cellular immunity, which emphasizes on the role of cellular immunity in COVID-19.
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