相关参考文献
注意:仅列出部分参考文献,下载原文获取全部文献信息。Regulatory T Cell Development
Peter A. Savage et al.
ANNUAL REVIEW OF IMMUNOLOGY, VOL 38 (2020)
Genetic Variation in Type 1 Diabetes Reconfigures the 3D Chromatin Organization of T Cells and Alters Gene Expression
Maria Fasolino et al.
IMMUNITY (2020)
Autoreactive CD8+ T cell exhaustion distinguishes subjects with slow type 1 diabetes progression
Alice E. Wiedeman et al.
JOURNAL OF CLINICAL INVESTIGATION (2020)
Epigenetic Regulation of T Cell Memory: Recalling Therapeutic Implications
David F. Tough et al.
TRENDS IN IMMUNOLOGY (2020)
Recent insights of T cell receptor-mediated signaling pathways for T cell activation and development
Jeong-Ryul Hwang et al.
EXPERIMENTAL AND MOLECULAR MEDICINE (2020)
Thymic Epithelial Cells Contribute to Thymopoiesis and T Cell Development
Hong-Xia Wang et al.
FRONTIERS IN IMMUNOLOGY (2020)
Regulation of T Helper Cell Fate by TCR Signal Strength
Nayan D. Bhattacharyya et al.
FRONTIERS IN IMMUNOLOGY (2020)
Beta cell-specific CD8+ T cells maintain stem cell memory-associated epigenetic programs during type 1 diabetes
Hossam A. Abdelsamed et al.
NATURE IMMUNOLOGY (2020)
The role of TH17 cells in multiple sclerosis: Therapeutic implications
Tobias Moser et al.
AUTOIMMUNITY REVIEWS (2020)
Follicular helper T cell profiles predict response to costimulation blockade in type 1 diabetes
Natalie M. Edner et al.
NATURE IMMUNOLOGY (2020)
Cytokines in type 1 diabetes: mechanisms of action and immunotherapeutic targets
Jingli Lu et al.
CLINICAL & TRANSLATIONAL IMMUNOLOGY (2020)
T-Cell-Specific PTPN2 Deficiency in NOD Mice Accelerates the Development of Type 1 Diabetes and Autoimmune Comorbidities
Florian Wiede et al.
DIABETES (2019)
T Follicular Helper Cell Biology: A Decade of Discovery and Diseases
Shane Crotty
IMMUNITY (2019)
Standardizing T-Cell Biomarkers in Type 1 Diabetes: Challenges and Recent Advances
Simi Ahmed et al.
DIABETES (2019)
Hybrid Insulin Peptides Are Autoantigens in Type 1 Diabetes
Rocky L. Baker et al.
DIABETES (2019)
How does the immune system learn to distinguish between good and evil? The first definitive studies of T cell central tolerance and positive selection
Pawel Kisielow
IMMUNOGENETICS (2019)
Enforcing the checkpoints: harnessing T-cell exhaustion for therapy of T1D
Peter S. Linsley et al.
CURRENT OPINION IN ENDOCRINOLOGY DIABETES AND OBESITY (2019)
TCF-1-Centered Transcriptional Network Drives an Effector versus Exhausted CD8 T Cell-Fate Decision
Zeyu Chen et al.
IMMUNITY (2019)
Central CD4+ T cell tolerance: deletion versus regulatory T cell differentiation
Ludger Klein et al.
NATURE REVIEWS IMMUNOLOGY (2019)
Directing T cell fate: How thymic antigen presenting cells coordinate thymocyte selection
Elise R. Breed et al.
SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY (2018)
CD4 T Cells Reactive to Hybrid Insulin Peptides Are Indicators of Disease Activity in the NOD Mouse
Rocky L. Baker et al.
DIABETES (2018)
Collateral Damage: Insulin-Dependent Diabetes Induced With Checkpoint Inhibitors
Angeliki Stamatouli et al.
DIABETES (2018)
Active Maintenance of T Cell Memory in Acute and Chronic Viral Infection Depends on Continuous Expression of FOXO1
Daniel T. Utzschneider et al.
CELL REPORTS (2018)
The protein tyrosine phosphatase PTPN22 negatively regulates presentation of immune complex derived antigens
Fiona Clarke et al.
SCIENTIFIC REPORTS (2018)
Therapies to Suppress β Cell Autoimmunity in Type 1 Diabetes
Charles J. Kroger et al.
FRONTIERS IN IMMUNOLOGY (2018)
Regulation of Effector and Memory CD8 T Cell Differentiation by IL-2-A Balancing Act
Vandana Kalia et al.
FRONTIERS IN IMMUNOLOGY (2018)
Epigenetic control of CD8+ T cell differentiation
Amanda N. Henning et al.
NATURE REVIEWS IMMUNOLOGY (2018)
The diverse functions of the PD1 inhibitory pathway
Arlene H. Sharpe et al.
NATURE REVIEWS IMMUNOLOGY (2018)
Regulatory mechanisms in T cell receptor signalling
Guillaume Gaud et al.
NATURE REVIEWS IMMUNOLOGY (2018)
Islet-Derived CD4 T Cells Targeting Proinsulin in Human Autoimmune Diabetes
Aaron W. Michels et al.
DIABETES (2017)
β-cell specific T-lymphocyte response has a distinct inflammatory phenotype in children with Type 1 diabetes compared with adults
S. Arif et al.
DIABETIC MEDICINE (2017)
Thymic Dendritic Cell Subsets Display Distinct Efficiencies and Mechanisms of Intercellular MHC Transfer
Charles J. Kroger et al.
JOURNAL OF IMMUNOLOGY (2017)
Endogenous Nur77 Is a Specific Indicator of Antigen Receptor Signaling in Human T and B Cells
Judith F. Ashouri et al.
JOURNAL OF IMMUNOLOGY (2017)
Ablation of Transcription Factor IRF4 Promotes Transplant Acceptance by Driving Allogenic CD4+ T Cell Dysfunction
Jie Wu et al.
IMMUNITY (2017)
Transcription Factor IRF4 Promotes CD8+ T Cell Exhaustion and Limits the Development of Memory-like T Cells during Chronic Infection
Kevin Man et al.
IMMUNITY (2017)
Autoreactive T cells in type 1 diabetes
Alberto Pugliese
JOURNAL OF CLINICAL INVESTIGATION (2017)
T cell costimulatory receptor CD28 is a primary target for PD-1-mediated inhibition
Enfu Hui et al.
SCIENCE (2017)
A divergent population of autoantigen-responsive CD4+ T cells in infants prior to β cell autoimmunity
Anne-Kristin Heninger et al.
SCIENCE TRANSLATIONAL MEDICINE (2017)
Transcription Factor T-bet Orchestrates Lineage Development and Function in the Immune System
Axel Kallies et al.
TRENDS IN IMMUNOLOGY (2017)
Tonic Signals: Why Do Lymphocytes Bother?
Darienne R. Myers et al.
TRENDS IN IMMUNOLOGY (2017)
The Mechanisms of T Cell Selection in the Thymus
Hiroyuki Takaba et al.
TRENDS IN IMMUNOLOGY (2017)
Ezh2 phosphorylation state determines its capacity to maintain CD8+ T memory precursors for antitumor immunity
Shan He et al.
NATURE COMMUNICATIONS (2017)
The Genetic Architecture of Type 1 Diabetes
Samuel T. Jerram et al.
GENES (2017)
The Role of Dendritic Cell Maturation in the induction of insulin-Dependent Diabetes Mellitus
Jacques C. Mbongue et al.
FRONTIERS IN IMMUNOLOGY (2017)
Cellular and Molecular Dynamics of Th17 Differentiation and its Developmental Plasticity in the intestinal immune Response
Suniti Bhaumik et al.
FRONTIERS IN IMMUNOLOGY (2017)
Type 1 Diabetes: A Chronic Anti-Self-Inflammatory Response
Matthew Clark et al.
FRONTIERS IN IMMUNOLOGY (2017)
Type 1 diabetes mellitus
Anastasia Katsarou et al.
NATURE REVIEWS DISEASE PRIMERS (2017)
T Cell-Mediated Beta Cell Destruction: Autoimmunity and Alloimmunity in the Context of Type 1 Diabetes
Adam L. Burrack et al.
FRONTIERS IN ENDOCRINOLOGY (2017)
Increased Effector Memory Insulin-Specific CD4+ T Cells Correlate With Insulin Autoantibodies in Patients With Recent-Onset Type 1 Diabetes
Justin A. Spanier et al.
DIABETES (2017)
Deciphering the Pathogenesis of Human Type 1 Diabetes (T1D) by Interrogating T Cells from the Scene of the Crime
Sally C. Kent et al.
CURRENT DIABETES REPORTS (2017)
The Role of Epigenetics in Type 1 Diabetes
Samuel T. Jerram et al.
CURRENT DIABETES REPORTS (2017)
Regulatory T cell dysfunction in type 1 diabetes: what's broken and how can we fix it?
Caroline M. Hull et al.
DIABETOLOGIA (2017)
Remodeling T cell compartments during anti-CD3 immunotherapy of type 1 diabetes
S. Alice Long et al.
CELLULAR IMMUNOLOGY (2017)
Follicular T Helper Cells: A New Marker of Type 1 Diabetes Risk?
Frank Heuts et al.
DIABETES (2017)
Foxp3 programs the development and function of CD4+CD25+ regulatory T cells
Jason D. Fontenot et al.
JOURNAL OF IMMUNOLOGY (2017)
CD4 T cell differentiation in type 1 diabetes
L. S. K. Walker et al.
CLINICAL AND EXPERIMENTAL IMMUNOLOGY (2016)
Insulitis and -Cell Mass in the Natural History of Type 1 Diabetes
Martha Campbell-Thompson et al.
DIABETES (2016)
TCR Signal Strength and T Cell Development
Nicholas R. J. Gascoigne et al.
ANNUAL REVIEW OF CELL AND DEVELOPMENTAL BIOLOGY, VOL 32 (2016)
CRISPR-Cas9-Mediated Modification of the NOD Mouse Genome With Ptpn22R619W Mutation Increases Autoimmune Diabetes
Xiaotian Lin et al.
DIABETES (2016)
Temporal increase in thymocyte negative selection parallels enhanced thymic SIRPα+ DC function
Charles J. Kroger et al.
EUROPEAN JOURNAL OF IMMUNOLOGY (2016)
T Cell Factor 1-Expressing Memory-like CD8+ T Cells Sustain the Immune Response to Chronic Viral Infections
Daniel T. Utzschneider et al.
IMMUNITY (2016)
Costimulatory and Coinhibitory Receptor Pathways in Infectious Disease
John Attanasio et al.
IMMUNITY (2016)
T cells in type 1 diabetes: Instructors, regulators and effectors: A comprehensive review
Iria Gomez-Tourino et al.
JOURNAL OF AUTOIMMUNITY (2016)
Antibody Binding to CD4 Induces Rac GTPase Activation and Alters T Cell Migration
Y. Maurice Morillon et al.
JOURNAL OF IMMUNOLOGY (2016)
Are Regulatory T Cells Defective in Type 1 Diabetes and Can We Fix Them?
Anabelle Visperas et al.
JOURNAL OF IMMUNOLOGY (2016)
Analysis of self-antigen specificity of islet-infiltrating T cells from human donors with type 1 diabetes
Jenny Aurielle B. Babon et al.
NATURE MEDICINE (2016)
Induction of autoimmune disease by deletion of CTLA-4 in mice in adulthood
Katrin Klocke et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2016)
Pathogenic CD4 T cells in type 1 diabetes recognize epitopes formed by peptide fusion
Thomas Delong et al.
SCIENCE (2016)
TCR Signal Strength Alters T-DC Activation and Interaction Times and Directs the Outcome of Differentiation
Nicholas van Panhuys
FRONTIERS IN IMMUNOLOGY (2016)
T Cells and Gene Regulation: The Switching On and Turning Up of Genes after T Cell Receptor Stimulation in CD8 T Cells
James M. Conley et al.
FRONTIERS IN IMMUNOLOGY (2016)
T cell receptor signalling in the control of regulatory T cell differentiation and function
Ming O. Li et al.
NATURE REVIEWS IMMUNOLOGY (2016)
AIRE expands: new roles in immune tolerance and beyond
Mark S. Anderson et al.
NATURE REVIEWS IMMUNOLOGY (2016)
Partial exhaustion of CD8 T cells and clinical response to teplizumab in new-onset type 1 diabetes
S. Alice Long et al.
SCIENCE IMMUNOLOGY (2016)
The TCF1-Bcl6 axis counteracts type I interferon to repress exhaustion and maintain T cell stemness
Tuoqi Wu et al.
SCIENCE IMMUNOLOGY (2016)
Anti-coreceptor therapy drives selective T cell egress by suppressing inflammation-dependent chemotactic cues
Aaron J. Martin et al.
JCI INSIGHT (2016)
Fezf2 Orchestrates a Thymic Program of Self-Antigen Expression for Immune Tolerance
Hiroyuki Takaba et al.
CELL (2015)
Lessons From Pancreas Transplantation in Type 1 Diabetes: Recurrence of Islet Autoimmunity
George W. Burke et al.
CURRENT DIABETES REPORTS (2015)
Current Concepts on the Pathogenesis of Type 1 Diabetes-Considerations for Attempts to Prevent and Reverse the Disease
Mark A. Atkinson et al.
DIABETES CARE (2015)
Haploinsufficiency of interferon regulatory factor 4 strongly protects against autoimmune diabetes in NOD mice
Satoru Akazawa et al.
DIABETOLOGIA (2015)
IL-21 production by CD4+ effector T cells and frequency of circulating follicular helper T cells are increased in type 1 diabetes patients
Ricardo C. Ferreira et al.
DIABETOLOGIA (2015)
The therapeutic potential of regulatory T cells for the treatment of autoimmune disease
Jeffrey A. Bluestone et al.
EXPERT OPINION ON THERAPEUTIC TARGETS (2015)
Thymic B Cells Are Licensed to Present Self Antigens for Central T Cell Tolerance Induction
Tomoyoshi Yamano et al.
IMMUNITY (2015)
The Chromatin-Modifying Enzyme Ezh2 Is Critical for the Maintenance of Regulatory T Cell Identity after Activation
Michel DuPage et al.
IMMUNITY (2015)
The role of Th17 cells in patients with relapsing-remitting multiple sclerosis: Interleukin-17A and interleukin-17F serum levels
Zohreh Babaloo et al.
IMMUNOLOGY LETTERS (2015)
The T Cell Repertoire-Diversifying Enzyme TSSP Contributes to Thymic Selection of Diabetogenic CD4 T Cell Specificities Reactive to ChgA and IAPP Autoantigens
Christophe Viret et al.
JOURNAL OF IMMUNOLOGY (2015)
T-cell exhaustion, co-stimulation and clinical outcome in autoimmunity and infection
Eoin F. McKinney et al.
NATURE (2015)
Fine mapping of type 1 diabetes susceptibility loci and evidence for colocalization of causal variants with lymphoid gene enhancers
Suna Onengut-Gumuscu et al.
NATURE GENETICS (2015)
Organ donor specimens: What can they tell us about type 1 diabetes?
Martha Campbell-Thompson
PEDIATRIC DIABETES (2015)
Regulatory T cells generated early in life play a distinct role in maintaining self-tolerance
Siyoung Yang et al.
SCIENCE (2015)
Type 1 diabetes immunotherapy using polyclonal regulatory T cells
Jeffrey A. Bluestone et al.
SCIENCE TRANSLATIONAL MEDICINE (2015)
Signaling in Lymphocyte Activation
Doreen Cantrell
COLD SPRING HARBOR PERSPECTIVES IN BIOLOGY (2015)
Genetic Variations of PTPN2 and PTPN22: Role in the Pathogenesis of Type 1 Diabetes and Crohn's Disease
Robert C. Sharp et al.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY (2015)
Thymic B cells and central T cell tolerance
Tomoyoshi Yamano et al.
FRONTIERS IN IMMUNOLOGY (2015)
TCR Signaling in T Cell Memory
Mark A. Daniels et al.
FRONTIERS IN IMMUNOLOGY (2015)
Antigen Presentation by MHC-Dressed Cells
Masafumi Nakayama
FRONTIERS IN IMMUNOLOGY (2015)
β-Cell-Specific CD8 T Cell Phenotype in Type 1 Diabetes Reflects Chronic Autoantigen Exposure
Ania Skowera et al.
DIABETES (2015)
Follicular helper T cell signature in type 1 diabetes
Rupert Kenefeck et al.
JOURNAL OF CLINICAL INVESTIGATION (2015)
Molecular and cellular insights into T cell exhaustion
E. John Wherry et al.
NATURE REVIEWS IMMUNOLOGY (2015)
The Immunological Synapse: A Molecular Machine Controlling T Cell Activation
Arash Grakoui et al.
JOURNAL OF IMMUNOLOGY (2015)
Blood and Islet Phenotypes Indicate Immunological Heterogeneity in Type 1 Diabetes
Sefina Arif et al.
DIABETES (2014)
Expression of IL-2 in β cells by AAV8 gene transfer in pre-diabetic NOD mice prevents diabetes through activation of FoxP3-positive regulatory T cells
R. R. Flores et al.
GENE THERAPY (2014)
IL-2 Induction of Blimp-1 Is a Key In Vivo Signal for CD8+ Short-Lived Effector T Cell Differentiation
Salix Boulet et al.
JOURNAL OF IMMUNOLOGY (2014)
Graded Levels of IRF4 Regulate CD8+ T Cell Differentiation and Expansion, but Not Attrition, in Response to Acute Virus Infection
Ribhu Nayar et al.
JOURNAL OF IMMUNOLOGY (2014)
Activating germline mutations in STAT3 cause early-onset multi-organ autoimmune disease
Sarah E. Flanagan et al.
NATURE GENETICS (2014)
A sharp T-cell antigen receptor signaling threshold for T-cell proliferation
Byron B. Au-Yeung et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2014)
Positive and negative selection of the T cell repertoire: what thymocytes see (and don't see)
Ludger Klein et al.
NATURE REVIEWS IMMUNOLOGY (2014)
Anti-cytokine therapies in T1D: Concepts and strategies
Gerald T. Nepom et al.
CLINICAL IMMUNOLOGY (2013)
DiaPep277® and immune intervention for treatment of type 1 diabetes
Nanette C. Schloot et al.
CLINICAL IMMUNOLOGY (2013)
β-Cell-Specific IL-2 Therapy Increases Islet Foxp3+Treg and Suppresses Type 1 Diabetes in NOD Mice
Mark C. Johnson et al.
DIABETES (2013)
Double deficiency in IL-17 and IFN-γ signalling significantly suppresses the development of diabetes in the NOD mouse
G. Kuriya et al.
DIABETOLOGIA (2013)
Interferon Regulatory Factor 4 Sustains CD8+ T Cell Expansion and Effector Differentiation
Shuyu Yao et al.
IMMUNITY (2013)
T-cell memory differentiation: insights from transcriptional signatures and epigenetics
Ben Youngblood et al.
IMMUNOLOGY (2013)
Thymic Development of Autoreactive T Cells in NOD Mice Is Regulated in an Age-Dependent Manner
Qiuming He et al.
JOURNAL OF IMMUNOLOGY (2013)
IL-21-Producing Th Cells in Immunity and Autoimmunity
Sue M. Liu et al.
JOURNAL OF IMMUNOLOGY (2013)
The transcription factor IRF4 is essential for TCR affinity-mediated metabolic programming and clonal expansion of T cells
Kevin Man et al.
NATURE IMMUNOLOGY (2013)
Inhibition of Increased Circulating Tfh Cell by Anti-CD20 Monoclonal Antibody in Patients with Type 1 Diabetes
Xinyu Xu et al.
PLOS ONE (2013)
Revisiting the notion of type 1 diabetes being a T-cell-mediated autoimmune disease
Oskar Skog et al.
CURRENT OPINION IN ENDOCRINOLOGY DIABETES AND OBESITY (2013)
Low-Affinity T Cells Are Programmed to Maintain Normal Primary Responses but Are Impaired in Their Recall to Low-Affinity Ligands
Karin M. Knudson et al.
CELL REPORTS (2013)
Generation and function of nducec regulatory T cells
Erica G. Schmitt et al.
FRONTIERS IN IMMUNOLOGY (2013)
Monitoring the dynamics of T cell clonal diversity using recombinant peptide:MHC technology
J. Lori Blanchfield et al.
FRONTIERS IN IMMUNOLOGY (2013)
T-bet: a bridge between innate and adaptive immunity
Vanja Lazarevic et al.
NATURE REVIEWS IMMUNOLOGY (2013)
T cell receptor signalling networks: branched, diversified and bounded
Rebecca J. Brownlie et al.
NATURE REVIEWS IMMUNOLOGY (2013)
IL-21 inhibits T cell IL-2 production and impairs Treg homeostasis
Kesley Attridge et al.
BLOOD (2012)
Central Role for Interleukin-2 in Type 1 Diabetes
Maigan A. Hulme et al.
DIABETES (2012)
Long-Term Remission of Diabetes in NOD Mice Is Induced by Nondepleting Anti-CD4 and Anti-CD8 Antibodies
Zuoan Yi et al.
DIABETES (2012)
T Cell Affinity Regulates Asymmetric Division, Effector Cell Differentiation, and Tissue Pathology
Carolyn G. King et al.
IMMUNITY (2012)
Plasmacytoid Dendritic Cells Transport Peripheral Antigens to the Thymus to Promote Central Tolerance
Husein Hadeiba et al.
IMMUNITY (2012)
Thymic negative selection is functional in NOD mice
Michael Mingueneau et al.
JOURNAL OF EXPERIMENTAL MEDICINE (2012)
STAT5 is a potent negative regulator of TFH cell differentiation
Robert J. Johnston et al.
JOURNAL OF EXPERIMENTAL MEDICINE (2012)
Demonstration of islet-autoreactive CD8 T cells in insulitic lesions from recent onset and long-term type 1 diabetes patients
Ken T. Coppieters et al.
JOURNAL OF EXPERIMENTAL MEDICINE (2012)
Self-reactive human CD4 T cell clones form unusual immunological synapses
David A. Schubert et al.
JOURNAL OF EXPERIMENTAL MEDICINE (2012)
Type 1 Diabetes-Associated IL2RA Variation Lowers IL-2 Signaling and Contributes to Diminished CD4+CD25+ Regulatory T Cell Function
Garima Garg et al.
JOURNAL OF IMMUNOLOGY (2012)
Novel Foxo1-dependent transcriptional programs control Treg cell function
Weiming Ouyang et al.
NATURE (2012)
TCR signaling via Tec kinase ITK and interferon regulatory factor 4 (IRF4) regulates CD8+ T-cell differentiation
Ribhu Nayar et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2012)
Dependence on nuclear factor of activated T-cells (NFAT) levels discriminates conventional T cells from Foxp3+ regulatory T cells
Martin Vaeth et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2012)
Antigen-Specific Therapeutic Approaches in Type 1 Diabetes
Xavier Clemente-Casares et al.
COLD SPRING HARBOR PERSPECTIVES IN MEDICINE (2012)
The Pathogenesis and Natural History of Type 1 Diabetes
Mark A. Atkinson
COLD SPRING HARBOR PERSPECTIVES IN MEDICINE (2012)
Genetics of Type 1 Diabetes
Janelle A. Noble et al.
COLD SPRING HARBOR PERSPECTIVES IN MEDICINE (2012)
Antigen Targets of Type 1 Diabetes Autoimmunity
Bart O. Roep et al.
COLD SPRING HARBOR PERSPECTIVES IN MEDICINE (2012)
Transcriptional control of effector and memory CD8+ T cell differentiation
Susan M. Kaech et al.
NATURE REVIEWS IMMUNOLOGY (2012)
The molecular basis of the memory T cell response: differential gene expression and its epigenetic regulation
Nan-ping Weng et al.
NATURE REVIEWS IMMUNOLOGY (2012)
Follicular Helper CD4 T Cells (T-FH)
Shane Crotty
ANNUAL REVIEW OF IMMUNOLOGY, VOL 29 (2011)
T Cell Recognition of Autoantigens in Human Type 1 Diabetes: Clinical Perspectives
Roberto Mallone et al.
CLINICAL & DEVELOPMENTAL IMMUNOLOGY (2011)
Interleukin-21 Is Critically Required in Autoimmune and Allogeneic Responses to Islet Tissue in Murine Models
Helen M. McGuire et al.
DIABETES (2011)
Expansion of Th17 Cells and Functional Defects in T Regulatory Cells Are Key Features of the Pancreatic Lymph Nodes in Patients With Type 1 Diabetes
Alessandra Ferraro et al.
DIABETES (2011)
An autoimmune-associated variant in PTPN2 reveals an impairment of IL-2R signaling in CD4+ T cells
S. A. Long et al.
GENES AND IMMUNITY (2011)
Differential Expression of Ly6C and T-bet Distinguish Effector and Memory Th1 CD4+ Cell Properties during Viral Infection
Heather D. Marshall et al.
IMMUNITY (2011)
IL-18 is required for self-reactive T cell expansion in NOD mice
Annette M. Marleau et al.
JOURNAL OF AUTOIMMUNITY (2011)
The susceptibility of Aire-/- mice to experimental myasthenia gravis involves alterations in regulatory T cells
Revital Aricha et al.
JOURNAL OF AUTOIMMUNITY (2011)
Thymus-specific serine protease controls autoreactive CD4 T cell development and autoimmune diabetes in mice
Christophe Viret et al.
JOURNAL OF CLINICAL INVESTIGATION (2011)
Aire-dependent production of XCL1 mediates medullary accumulation of thymic dendritic cells and contributes to regulatory T cell development
Yu Lei et al.
JOURNAL OF EXPERIMENTAL MEDICINE (2011)
Functional Redundancy between Thymic CD8α+ and Sirpα+ Conventional Dendritic Cells in Presentation of Blood-Derived Lysozyme by MHC Class II Proteins
Danielle F. Atibalentja et al.
JOURNAL OF IMMUNOLOGY (2011)
Cutting Edge: Accelerated Autoimmune Diabetes in the Absence of LAG-3
Maria Bettini et al.
JOURNAL OF IMMUNOLOGY (2011)
Beta cells under attack: toward a better understanding of type 1 diabetes immunopathology
Ken T. Coppieters et al.
SEMINARS IN IMMUNOPATHOLOGY (2011)
Immunopathology of the human pancreas in type-I diabetes
Sarah J. Richardson et al.
SEMINARS IN IMMUNOPATHOLOGY (2011)
Regulatory T cells: stability revisited
Samantha L. Bailey-Bucktrout et al.
TRENDS IN IMMUNOLOGY (2011)
Insulitis in human type 1 diabetes The quest for an elusive lesion
Peter In't Veld
ISLETS (2011)
Differentiation of Effector CD4 T Cell Populations
Jinfang Zhu et al.
ANNUAL REVIEW OF IMMUNOLOGY, VOL 28 (2010)
Defects in IL-2R Signaling Contribute to Diminished Maintenance of FOXP3 Expression in CD4+ CD25+ Regulatory T-Cells of Type 1 Diabetic Subjects
S. Alice Long et al.
DIABETES (2010)
Recurrence of Type 1 Diabetes After Simultaneous Pancreas-Kidney Transplantation, Despite Immunosuppression, Is Associated With Autoantibodies and Pathogenic Autoreactive CD4 T-Cells
Francesco Vendrame et al.
DIABETES (2010)
Simultaneous Detection of Circulating Autoreactive CD8+ T-Cells Specific for Different Islet Cell-Associated Epitopes Using Combinatorial MHC Multimers
Jurjen H. Velthuis et al.
DIABETES (2010)
Genetics of Type 1 Diabetes: What's Next?
Flemming Pociot et al.
DIABETES (2010)
Interleukin-2 and Inflammation Induce Distinct Transcriptional Programs that Promote the Differentiation of Effector Cytolytic T Cells
Matthew E. Pipkin et al.
IMMUNITY (2010)
Peripheral CD4+T-cell differentiation regulated by networks of cytokines and transcription factors
Jinfang Zhu et al.
IMMUNOLOGICAL REVIEWS (2010)
Roles for cathepsins S, L, and B in insulitis and diabetes in the NOD mouse
Lianne C. Hsing et al.
JOURNAL OF AUTOIMMUNITY (2010)
TCR ligand density and affinity determine peripheral induction of Foxp3 in vivo
Rachel A. Gottschalk et al.
JOURNAL OF EXPERIMENTAL MEDICINE (2010)
Cutting Edge: Increased IL-17-Secreting T Cells in Children with New-Onset Type 1 Diabetes
Ashish K. Marwaha et al.
JOURNAL OF IMMUNOLOGY (2010)
Cutting Edge: TCR Ligation Triggers Digital Activation of NF-κB
Lara M. Kingeter et al.
JOURNAL OF IMMUNOLOGY (2010)
Analysis of islet inflammation in human type 1 diabetes
A. Willcox et al.
CLINICAL AND EXPERIMENTAL IMMUNOLOGY (2009)
Interleukin-21 Is Required for the Development of Type 1 Diabetes in NOD Mice
Andrew P. R. Sutherland et al.
DIABETES (2009)
Inhibition of Th17 Cells Regulates Autoimmune Diabetes in NOD Mice
Juliet A. Emamaullee et al.
DIABETES (2009)
Thymus-specific deletion of insulin induces autoimmune diabetes
Yong Fan et al.
EMBO JOURNAL (2009)
Reproducible association with type 1 diabetes in the extended class I region of the major histocompatibility complex
M. K. Viken et al.
GENES AND IMMUNITY (2009)
Transcriptional Repressor Blimp-1 Promotes CD8+ T Cell Terminal Differentiation and Represses the Acquisition of Central Memory T Cell Properties
Rachel L. Rutishauser et al.
IMMUNITY (2009)
Nuclear Factor-κB Modulates Regulatory T Cell Development by Directly Regulating Expression of Foxp3 Transcription Factor
Meixiao Long et al.
IMMUNITY (2009)
Development of Foxp3+ Regulatory T Cells Is Driven by the c-Rel Enhanceosome
Qingguo Ruan et al.
IMMUNITY (2009)
The thymic medulla: a unique microenvironment for intercellular self-antigen transfer
Christian Koble et al.
JOURNAL OF EXPERIMENTAL MEDICINE (2009)
Neonatal tolerance revisited: a perinatal window for Aire control of autoimmunity
Mireia Guerau-de-Arellano et al.
JOURNAL OF EXPERIMENTAL MEDICINE (2009)
A cis-Acting Regulatory Variant in the IL2RA Locus
Hui-Qi Qu et al.
JOURNAL OF IMMUNOLOGY (2009)
Soluble IL-2RA Levels in Multiple Sclerosis Subjects and the Effect of Soluble IL-2RA on Immune Responses
Lisa M. Maier et al.
JOURNAL OF IMMUNOLOGY (2009)
T-bet-Deficient NOD Mice Are Protected from Diabetes Due to Defects in Both T Cell and Innate Immune System Function
Jonathan H. Esensten et al.
JOURNAL OF IMMUNOLOGY (2009)
Thymus-Blood Protein Interactions Are Highly Effective in Negative Selection and Regulatory T Cell Induction
Danielle F. Atibalentja et al.
JOURNAL OF IMMUNOLOGY (2009)
Genome-wide association study and meta-analysis find that over 40 loci affect risk of type 1 diabetes
Jeffrey C. Barrett et al.
NATURE GENETICS (2009)
Coregulation of CD8+ T cell exhaustion by multiple inhibitory receptors during chronic viral infection
Shawn D. Blackburn et al.
NATURE IMMUNOLOGY (2009)
The function of follicular helper T cells is regulated by the strength of T cell antigen receptor binding
Nicolas Fazilleau et al.
NATURE IMMUNOLOGY (2009)
Genetics of Type 1A Diabetes
Patrick Concannon et al.
NEW ENGLAND JOURNAL OF MEDICINE (2009)
CD28 Co-Stimulation Down Regulates Th17 Development
Salim Bouguermouh et al.
PLOS ONE (2009)
Non-obese diabetic mice select a low-diversity repertoire of natural regulatory T cells
Cristina Ferreira et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2009)
Bcl6 and Blimp-1 Are Reciprocal and Antagonistic Regulators of T Follicular Helper Cell Differentiation
Robert J. Johnston et al.
SCIENCE (2009)
A Vital Role for Interleukin-21 in the Control of a Chronic Viral Infection
John S. Yi et al.
SCIENCE (2009)
IL-21R on T Cells Is Critical for Sustained Functionality and Control of Chronic Viral Infection
Anja Froehlich et al.
SCIENCE (2009)
The pancreas in human type 1 diabetes: providing new answers to age-old questions
Mark A. Atkinson et al.
CURRENT OPINION IN ENDOCRINOLOGY DIABETES AND OBESITY (2009)
Recurrence of autoreactive antigen-specific CD4+T cells in autoimmune diabetes after pancreas transplantation
Elsa Laughlin et al.
CLINICAL IMMUNOLOGY (2008)
Gene gun-mediated DNA vaccination enhances antigen-specific immunotherapy at a late preclinical stage of type 1 diabetes in nonobese diabetic mice
Kevin S. Goudy et al.
CLINICAL IMMUNOLOGY (2008)
Intercellular MHC transfer between thymic epithelial and dendritic cells
Virginie Millet et al.
EUROPEAN JOURNAL OF IMMUNOLOGY (2008)
Coordinated but physically separable interaction with H3K27-demethylase and H3K4-methyltransferase activities are required for T-box protein-mediated activation of developmental gene expression
Sara A. Miller et al.
GENES & DEVELOPMENT (2008)
Central role of defective interleukin-2 production in the triggering of islet autoimmune destruction
Qizhi Tang et al.
IMMUNITY (2008)
The Effector T Cells of Diabetic Subjects Are Resistant to Regulation via CD4+FOXP3+ Regulatory T Cells
Anya Schneider et al.
JOURNAL OF IMMUNOLOGY (2008)
IL-6 blockade inhibits the induction of myelin antigen-specific Th17 cells and Th1 cells in experimental autoimmune encephalomyelitis
Satoshi Serada et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2008)
The defect in T-cell regulation in NOD mice is an effect on the T-cell effectors
Anna Morena D'Alise et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2008)
IL-21 signaling is critical for the development of type I diabetes in the NOD mouse
Rosanne Spolski et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2008)
How regulatory T cells work
Dario A. A. Vignali et al.
NATURE REVIEWS IMMUNOLOGY (2008)
Type 1 diabetes as a relapsing-remitting disease?
Matthias von Herrath et al.
NATURE REVIEWS IMMUNOLOGY (2007)
Evidence for in vivo primed and expanded autoreactive T cells as a specific feature of patients with type 1 diabetes
Paolo Monti et al.
JOURNAL OF IMMUNOLOGY (2007)
Genetic variation in PTPN22 corresponds to altered function of T and B lymphocytes
Mary Rieck et al.
JOURNAL OF IMMUNOLOGY (2007)
Large-scale genetic fine mapping and genotype-phenotype associations implicate polymorphism in the IL2RA region in type 1 diabetes
Christopher E. Lowe et al.
NATURE GENETICS (2007)
Polymorphisms in the cathepsin L2 (CTSL2) gene show association with type 1 diabetes and early-onset myasthenia gravis
Marte K. Viken et al.
HUMAN IMMUNOLOGY (2007)
Inflammation directs memory precursor and short-lived effector CD8+ T cell fates via the graded expression of T-bet transcription factor
Nikhil S. Joshi et al.
IMMUNITY (2007)
Robust associations of four new chromosome regions from genome-wide analyses of type 1 diabetes
John A. Todd et al.
NATURE GENETICS (2007)
Review of 54 patients with complete DiGeorge anomaly enrolled in protocols for thymus transplantation: outcome of 44 consecutive transplants
M. Louise Markert et al.
BLOOD (2007)
No alterations in the frequency of FOXP3+ regulatory T-cells in type 1 diabetes
Todd Brusko et al.
DIABETES (2007)
Transcription factors T-bet and Runx3 cooperate to activate lfng and silence ll4 in T helper type 1 cells
Ivana M. Djuretic et al.
NATURE IMMUNOLOGY (2007)
Natural regulatory T cells: mechanisms of suppression
Makoto Miyara et al.
TRENDS IN MOLECULAR MEDICINE (2007)
Insulin-induced remission in new-onset NOD mice is maintained by the PD-1-PD-L1 pathway
Brian T. Fife et al.
JOURNAL OF EXPERIMENTAL MEDICINE (2006)
Clonal deletion of thymocytes by circulating dendritic cells homing to the thymus
Roberto Bonasio et al.
NATURE IMMUNOLOGY (2006)
Role of PTPN22 in type 1 diabetes and other autoimmune diseases
Nunzio Bottini et al.
SEMINARS IN IMMUNOLOGY (2006)
Autoimmune-associated lymphoid tyrosine phosphatase is a gain-of-function variant
T Vang et al.
NATURE GENETICS (2005)
Effector and memory CD8+ T cell fate coupled by T-bet and eomesodermin
AM Intlekofer et al.
NATURE IMMUNOLOGY (2005)
Follicular B helper T cells in antibody responses and autoimmunity
CG Vinuesa et al.
NATURE REVIEWS IMMUNOLOGY (2005)
Cathepsin L is essential for onset of autoimmune diabetes in NOD mice
R Maehr et al.
JOURNAL OF CLINICAL INVESTIGATION (2005)
Central tolerance: Learning self-control in the thymus
KA Hogquist et al.
NATURE REVIEWS IMMUNOLOGY (2005)
Type 1 diabetes - Evidence for susceptibility loci from four genome-wide linkage scans in 1,435 multiplex families
P Concannon et al.
DIABETES (2005)
Establishment of NOD-Pdcd1-/- mice as an efficient animal model of type I diabetes
J Wang et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2005)
Functional defects and the influence of age on the frequency of CD4+CD25+ T-Cells in type 1 diabetes
TM Brusko et al.
DIABETES (2005)
Signals from CD28 induce stable epigenetic modification of the IL-2 promoter
RM Thomas et al.
JOURNAL OF IMMUNOLOGY (2005)
A well adapted regulatory contrivance: regulatory T cell development and the forkhead family transcription factor Foxp3
JD Fontenot et al.
NATURE IMMUNOLOGY (2005)
Defective central tolerance induction in NOD mice: Genomics and genetics
S Zucchelli et al.
IMMUNITY (2005)
CD4+CD25high regulatory T cells in human autoimmune diabetes
AL Putnam et al.
JOURNAL OF AUTOIMMUNITY (2005)
Defective suppressor function in CD4(+)CD25(+) T-cells from patients with type 1 diabetes
S Lindley et al.
DIABETES (2005)
A functional variant of lymphoid tyrosine phosphatase is associated with type I diabetes
N Bottini et al.
NATURE GENETICS (2004)
PEST domain-enriched tyrosine phosphatase (PEP) regulation of effector/memory T cells
K Hasegawa et al.
SCIENCE (2004)
Medullary epithelial cells of the human thymus express a highly diverse selection of tissue-specific genes colocalized in chromosomal clusters
J Gotter et al.
JOURNAL OF EXPERIMENTAL MEDICINE (2004)
Replication of an association between the lymphoid tyrosine phosphatase locus (LYP/PTPN22) with type 1 diabetes, and evidence for its role as a general autoimmunity locus
D Smyth et al.
DIABETES (2004)
Central tolerance to tissue-specific antigens mediated by direct and indirect antigen presentation
AM Gallegos et al.
JOURNAL OF EXPERIMENTAL MEDICINE (2004)
What is the importance of the immunological synapse?
DM Davis et al.
TRENDS IN IMMUNOLOGY (2004)
Similarities and differences in CD4+ and CD8+ effector and memory T cell generation
RA Seder et al.
NATURE IMMUNOLOGY (2003)
The programmed death-1 (PD-1) pathway regulates autoimmune diabetes in nonobese diabetic (NOD) mice
MJI Ansari et al.
JOURNAL OF EXPERIMENTAL MEDICINE (2003)
Association of the T-cell regulatory gene CTLA4 with susceptibility to autoimmune disease
H Ueda et al.
NATURE (2003)
Foxp3 programs the development and function of CD4+CD25+ regulatory T cells
JD Fontenot et al.
NATURE IMMUNOLOGY (2003)
Tim-3 inhibits T helper type 1-mediated auto- and alloimmune responses and promotes immunological tolerance
A Sanchez-Fueyo et al.
NATURE IMMUNOLOGY (2003)
A common autoimmunity predisposing signal peptide variant of the cytotoxic T-lymphocyte antigen 4 results in inefficient glycosylation of the susceptibility allele
S Anjos et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2002)
Projection of an immunological self shadow within the thymus by the aire protein
MS Anderson et al.
SCIENCE (2002)
Clinical and molecular features of the immunodysregulation, polyendocrinopathy, enteropathy, X linked (IPEX) syndrome
RS Wildin et al.
JOURNAL OF MEDICAL GENETICS (2002)
Genetics of type 1 diabetes mellitus
F Pociot et al.
GENES AND IMMUNITY (2002)
Polymorphisms in the gene encoding thymus-specific serine protease in the extended HLA complex: a potential candidate gene for autoimmune and HLA-associated diseases
BA Lie et al.
GENES AND IMMUNITY (2002)
T-bet is a STAT1-induced regulator of IL-12R expression in naive CD4+ T cells
M Afkarian et al.
NATURE IMMUNOLOGY (2002)
GAD65-reactive T cells are activated in patients with autoimmune type 1a diabetes
V Viglietta et al.
JOURNAL OF CLINICAL INVESTIGATION (2002)
Aire deficient mice develop multiple features of APECED phenotype and show altered immune response
C Ramsey et al.
HUMAN MOLECULAR GENETICS (2002)
A defect in central tolerance in NOD mice
H Kishimoto et al.
NATURE IMMUNOLOGY (2001)
Promiscuous gene expression in medullary thymic epithelial cells mirrors the peripheral self
J Derbinski et al.
NATURE IMMUNOLOGY (2001)
Linkage disequilibrium of a type 1 diabetes susceptibility locus with a regulatory IL12B allele
G Morahan et al.
NATURE GENETICS (2001)
X-linked neonatal diabetes mellitus, enteropathy and endocrinopathy syndrome is the human equivalent of mouse scurfy
RS Wildin et al.
NATURE GENETICS (2001)
Disruption of a new forkhead/winged-helix protein, scurfin, results in the fatal lymphoproliferative disorder of the scurfy mouse
ME Brunkow et al.
NATURE GENETICS (2001)
B7/CD28 costimulation is essential for the homeostasis of the CD4+CD25+ immunoregulatory T cells that control autoimmune diabetes
B Salomon et al.
IMMUNITY (2000)