4.8 Article

Relationship Between Pregnancy and Acute Disseminated Encephalomyelitis: A Single-Case Study

期刊

FRONTIERS IN IMMUNOLOGY
卷 11, 期 -, 页码 -

出版社

FRONTIERS MEDIA SA
DOI: 10.3389/fimmu.2020.609476

关键词

acute disseminated encephalomyelitis; pregnancy; immunological pathogenesis; T-helper lymphocytes; Immune Tolerance

资金

  1. National Natural Science Foundation of China [81571181]

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This study investigated the potential role of immune changes and activation of the HMGB1/TLR4/Nf-kappa B/IL-6 pathway at the maternal-fetal interface in the pathogenesis of pregnancy-related ADEM. The results showed increased expression levels of HMGB1, TLR4, Nf-kappa B, AQP4, and IL-6 in the patient with pregnancy-related ADEM compared to a woman with a normal pregnancy, indicating a potential association between local immune changes and ADEM pathogenesis.
The relationship between pregnancy and autoimmune diseases is unclear. This study investigated the possible role of local immune changes and the activation state of the HMGB1/TLR4/Nf-kappa B/IL-6 pathway at the maternal-fetal interface during pregnancy in the pathogenesis of acute disseminated encephalomyelitis (ADEM). Clinical data and blood samples of a patient with ADEM were collected to observe the dynamic changes in lymphocyte populations after an abortion. The expression of HMGB1, TLR4, Nf-kappa B, AQP4, IL-2, IL-4, IL-6, and TNF-alpha in the fetal membrane and placenta was compared between the patient with pregnancy-related ADEM and a woman with a normal pregnancy using Real-time qPCR and western blotting (WB). The patient was diagnosed with ADEM in the early stage of pregnancy after showing limb weakness symptoms. In the third month of gestation, the symptoms worsened, with a disturbance of consciousness and breathing. After the abortion, the patient relapsed with vertigo and visual rotation. Analysis of lymphocyte subsets by flow cytometry showed that B lymphocytes increased, while natural killer T lymphocytes decreased. WB and Real-time qPCR showed that the expression levels of HMGB1, TLR4, Nf-kappa B, AQP4, and IL-6 in the fetal membrane and placenta were higher in the patient with pregnancy-related ADEM than in the woman with a normal pregnancy, while those of IL-2 were lower in the patient than in the woman with a normal pregnancy. The local immune changes and the activation of the HMGB1/TLR4/Nf-kappa B/IL-6 pathway at the maternal-fetal interface may be related to the pathogenesis of ADEM.

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