期刊
DRUG DELIVERY AND TRANSLATIONAL RESEARCH
卷 11, 期 2, 页码 471-497出版社
SPRINGER HEIDELBERG
DOI: 10.1007/s13346-021-00908-7
关键词
Oral delivery; Liposome; Solid-lipid nanoparticle; Nanoemulsion; Nanocapsule; Self-emulsifying system
资金
- University of Castilla-La Mancha (UCLM) [01110AB026, 01110AB039]
- UCLM 10 [OE154, 2018/152504]
Lipid-based nanocarriers have advantages like low toxicity and strong biocompatibility, making them ideal carriers for drugs with poor oral bioavailability. However, efficient oral drug delivery through these carriers is challenging due to multiple physicochemical barriers along the gastrointestinal tract. Rational design of nanocarriers can turn these limitations into opportunities, ultimately determining their future clinical success.
Lipid-based nanocarriers have gained much interest as carriers of drugs with poor oral bioavailability because of their remarkable advantages like low toxicity, affordable scale-up manufacture, strong biocompatibility or high drug loading efficiency. The potential of these nanocarriers lies in their ability to improve the gastrointestinal stability, solubility and permeability of their cargo drugs. However, achieving efficient oral drug delivery through lipid-based nanocarriers is a challenging task, since they encounter multiple physicochemical barriers along the gastrointestinal tract, e.g. the gastric acidic content, the intestinal mucus layer or the enzymatic degradation, that they must surmount to reach their target. These limitations may be turned into opportunities through a rational design of lipid-based nanocarriers. For that purpose, this review focuses on the main challenges of the oral route indicating the strategies undertaken for lipid-based nanocarriers in order to overcome them. Understanding their shortcomings and identifying their strengths will determine the future clinical success of lipid-based nanocarriers.
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