期刊
ADVANCED SCIENCE
卷 8, 期 8, 页码 -出版社
WILEY
DOI: 10.1002/advs.202004042
关键词
; 3D printing; adamantane; biomaterials; cyclodextrin; host-guest; peptide amphiphile; superstructure
资金
- Center for Regenerative Nanomedicine at the Simpson Querrey Institute at Northwestern
- National Science Foundation [DGE-1842165]
- American Australian Association Fellowship
- Northwestern University Department of Materials Science and Engineering Meister Research Grant
- Department of Defense (DoD), Army Research Office, through the National Defense Science and Engineering Graduate (NDSEG) Fellowship [32 CFR 168a]
- Paralyzed Veterans of America (PVA) Research Foundation [PVA17_RF_0008]
- Northwestern University Medical Scientist Training Program [T32GM008152]
- Soft and Hybrid Nanotechnology Experimental (SHyNE) Resource [NSF ECCS-1542205]
- Simpson Querrey Institute, Northwestern University Office for Research, U.S. Army Research Office
- U.S. Army Medical Research and Material Command
- NCI Cancer Center Support Grant [P30 CA060553]
- MRSEC program at the Materials Research Center [NSF DMR-1720139]
- International Institute for Nanotechnology (IIN)
- Keck Foundation
- State of Illinois, through the IIN
- State of Illinois
- Northwestern University
- Dow Chemical Company
- DuPont de Nemours, Inc.
- DOE Office of Science [DE-AC02-06CH11357]
The study reports a supramolecular system where interactions between peptide amphiphiles and beta-cyclodextrin with adamantane lead to the formation of a mechanically robust hydrogel with highly porous architecture, which can be 3D printed and exhibits significant bioactivity towards neurons. This nanostructured hydrogel based on supramolecular assembly has potential applications in neuronal research and biomaterial design.
Dynamic and reversible assembly of molecules is ubiquitous in the hierarchical superstructures of living systems and plays a key role in cellular functions. Recent work from the laboratory reported on the reversible formation of such superstructures in systems of peptide amphiphiles conjugated to oligonucleotides and electrostatically complimentary peptide sequences. Here, a supramolecular system is reported upon where exchange dynamics and host-guest interactions between beta-cyclodextrin and adamantane on peptide amphiphiles lead to superstructure formation. Superstructure formation with bundled nanoribbons generates a mechanically robust hydrogel with a highly porous architecture that can be 3D printed. Functionalization of the porous superstructured material with a biological signal results in a matrix with significant in vitro bioactivity toward neurons that could be used as a supramolecular model to design novel biomaterials.
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