4.8 Review

Crosstalk between Bone and Nerves within Bone

期刊

ADVANCED SCIENCE
卷 8, 期 7, 页码 -

出版社

WILEY
DOI: 10.1002/advs.202003390

关键词

bioactive factors; bone metabolism; crosstalk; nerve growth; peripheral nerves

资金

  1. National Nature Science Foundation of China [81722015, 81870805, 81870787, 81671012, 81720108011]
  2. Shaanxi Key Scientific and Technological Innovation Team [2020TD-033]
  3. Innovative research team of high-level local universities in shanghai, Oral and maxillofacial regeneration and functional restoration

向作者/读者索取更多资源

This review comprehensively analyzes the possible crosstalk between bone and intrabony peripheral nerves, highlighting the role of peripheral nerves in bone development and repair through signals such as neurotransmitters, neuropeptides, and neurotrophins. In return, bone supports nerves mechanically and offers a protective environment. This crosstalk is not limited to physiological conditions, but also plays a role in various bone diseases, providing potential avenues for tissue engineering and disease treatment.
For the past two decades, the function of intrabony nerves on bone has been a subject of intense research, while the function of bone on intrabony nerves is still hidden in the corner. In the present review, the possible crosstalk between bone and intrabony peripheral nerves will be comprehensively analyzed. Peripheral nerves participate in bone development and repair via a host of signals generated through the secretion of neurotransmitters, neuropeptides, axon guidance factors and neurotrophins, with additional contribution from nerve-resident cells. In return, bone contributes to this microenvironmental rendezvous by housing the nerves within its internal milieu to provide mechanical support and a protective shelf. A large ensemble of chemical, mechanical, and electrical cues works in harmony with bone marrow stromal cells in the regulation of intrabony nerves. The crosstalk between bone and nerves is not limited to the physiological state, but also involved in various bone diseases including osteoporosis, osteoarthritis, heterotopic ossification, psychological stress-related bone abnormalities, and bone related tumors. This crosstalk may be harnessed in the design of tissue engineering scaffolds for repair of bone defects or be targeted for treatment of diseases related to bone and peripheral nerves.

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