期刊
ADVANCED SCIENCE
卷 8, 期 11, 页码 -出版社
WILEY
DOI: 10.1002/advs.202003503
关键词
antiviral materials; charged block polymers; microphase‐ ordered materials; polyanions; thermoplastic elastomers
资金
- Nonwovens Institute
- Comparative Medicine Institute, Halyard Health
- Kraton Corporation at NC State University
- Dr. Griffiths' start-up funds at Boston University
Research shows that a diverse family of nanostructured anionic polymers can rapidly inactivate coronaviruses within minutes. Applying these polymers to frequently touched surfaces in medical, educational, and public transportation facilities, or personal protective equipment, can provide rapid and continuous protection.
While the ongoing COVID-19 pandemic affirms an urgent global need for effective vaccines as second and third infection waves are spreading worldwide and generating new mutant virus strains, it has also revealed the importance of mitigating the transmission of SARS-CoV-2 through the introduction of restrictive social practices. Here, it is demonstrated that an architecturally- and chemically-diverse family of nanostructured anionic polymers yield a rapid and continuous disinfecting alternative to inactivate coronaviruses and prevent their transmission from contact with contaminated surfaces. Operating on a dramatic pH-drop mechanism along the polymer/pathogen interface, polymers of this archetype inactivate the SARS-CoV-2 virus, as well as a human coronavirus surrogate (HCoV-229E), to the minimum detection limit within minutes. Application of these anionic polymers to frequently touched surfaces in medical, educational, and public-transportation facilities, or personal protection equipment, can provide rapid and repetitive protection without detrimental health or environmental complications.
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