期刊
ACS BIOMATERIALS SCIENCE & ENGINEERING
卷 7, 期 3, 页码 926-938出版社
AMER CHEMICAL SOC
DOI: 10.1021/acsbiomaterials.0c01527
关键词
Biomaterials; plant-derived; scaffolds; tissue engineering; decellularization
资金
- Tubitak 2232 International Fellowship for Outstanding Researchers Award [118C391]
- Marie Sklodowska-Curie Individual Fellowship for Experienced Researchers
- Royal Academy Newton-Katip Celebi Transforming Systems Through Partnership award [120N019]
- Marie Sklodowska-Curie Individual Fellowship [101003361]
This study explores the principles, applications, and advantages of plant-based decellularized scaffolds, including the use of cellulose skeleton as a scaffold, advantages over synthetic polymers or animal-derived scaffolds, and adjustable variables to modify scaffold properties.
A wide range of platforms has been developed for 3D culture of cells in vitro to aggregate and align cells to resemble in vivo conditions in order to enhance communication between cells and promote differentiation. The cellulose skeleton of plant tissue can serve as an attainable scaffold for mammalian cells after decellularization, which is advantageous when compared to synthetic polymers or animal-derived scaffolds. Adjustable variables to modify the physical and biochemical properties of the resulting scaffolds include the protocol for the sodium dodecyl sulfate (SDS)-based decellularization procedure, surface coatings for cell attachment, plant type for decellularization, differentiation media, and integrity and shape of the substrate. These tunable cellulose platforms can host a wide range of mammalian cell types from muscle to bone cells, as well as malignancies. Here, fundamentals and applications of decellularized plant-based scaffolds are discussed. These biocompatible, naturally perfused, tunable, and easily prepared decellularized scaffolds may allow eco-friendly manufacturing frameworks for application in tissue engineering and organs-on-a-chip.
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