期刊
ACS BIOMATERIALS SCIENCE & ENGINEERING
卷 7, 期 3, 页码 1147-1158出版社
AMER CHEMICAL SOC
DOI: 10.1021/acsbiomaterials.0c01502
关键词
silk; desferrioxamine; vascularization; inflammation; diabetic foot ulcers
资金
- National Key R&D Program of China [2016YFE0204400]
- Postgraduate Research & Practice Innovation Program of Jiangsu Province [KYCX20_2664]
- General Program of Natural Science Foundation of Fujian Province [2020 J011226]
- Health Guidance Project of Xiamen [3502Z20209001]
The use of DFO-laden silk nanofiber hydrogels in treating diabetic wounds can alleviate dysangiogenesis and chronic inflammation, promoting faster wound healing and increased collagen deposition. Both in vitro and in vivo studies suggest the potential clinical applications of these DFO-laden hydrogels in diabetic ulcer treatment.
Dysangiogenesis and chronic inflammation are two critical reasons for diabetic foot ulcers. Desferrioxamine (DFO) was used clinically in the treatment of diabetic foot ulcers by repeated injections because of its capacity to induce vascularization. Biocompatible carriers that release DFO slowly and facilitate healing simultaneously are preferable options to accelerate the healing of diabetic wounds. Here, DFO-laden silk nanofiber hydrogels that provided a sustained release of DFO for more than 40 days were used to treat diabetic wounds. The DFO-laden hydrogels stimulated the healing of diabetic wounds. In vitro cell studies revealed that the DFO-laden hydrogels modulated the migration and gene expression of endothelial cells, and they also tuned the inflammation behavior of macrophages. These results were confirmed in an in vivo diabetic wound model. The DFO-laden hydrogels alleviated dysangiogenesis and chronic inflammation in the diabetic wounds, resulting in a more rapid wound healing and increased collagen deposition. Both in vitro and in vivo studies suggested potential clinical applications of these DFO-laden hydrogels in the treatment of diabetic ulcers.
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