期刊
ENVIRONMENTAL RESEARCH
卷 151, 期 -, 页码 251-264出版社
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.envres.2016.07.011
关键词
Endocrine disruptors; Reproductive alterations; Obesogen; Breast cancer
资金
- EU [603437]
- Globaqua project [603629]
- Generalitat de Catalunya (Consolidated Research Groups) [2014 SGR 418, 2014 SGR 291 - ICRA]
- CARIPLO
Endocrine disrupting chemicals (EDCs) are released into the environment from different sources. They are mainly used in packaging industries, pesticides and food constituents. Clinical evidence, experimental models, and epidemiological studies suggest that EDCs have major risks for humans by targeting different organs and systems in the body (e.g. reproductive system, breast tissue, adipose tissue, pancreas, etc.). Due to the ubiquity of human exposure to these compounds the aim of this review is to describe the most recent data on the effects induced by phthalates, bisphenol A and parabens in a critical window of exposure: in utero, during pregnancy, infants, and children. The interactions and mechanisms of toxicity of EDCs in relation to human general health problems, especially those broadening the term of endocrine disruption to 'metabolic disruption', should be deeply investigated. These include endocrine disturbances, with particular reference to reproductive problems and breast, testicular and ovarian cancers, and metabolic diseases such as obesity or diabetes. (C) 2016 Elsevier Inc. All rights reserved.
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