期刊
ENVIRONMENTAL RESEARCH
卷 151, 期 -, 页码 601-609出版社
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.envres.2016.08.033
关键词
Body Mass Index; Endocrine Disruptors; Epidemiology; Fetal growth; Infant growth; Phthalates
资金
- ANSES (PEnDevE project for Perturbateurs Endocriniens et Developpement de l'Enfant) [EST-2010/2/126]
- European Research Council [311765-E-DOHaD]
- FRM
- Inserm
- IReSP
- Nestle
- French Ministry of Health
- ANR
- Univ. Paris-Sud
- InVS
- ANSES
- MGEN
Objective: To study associations between prenatal exposure to phthalates and fetal and postnatal growth up to age 5 years in male offspring. Methods: Eleven phthalate metabolites were quantified in spot maternal urine samples collected during gestation among 520 women of the EDEN mother-child cohort who gave birth to a boy. Fetal growth was assessed from repeated ultrasound measurements and measurements at birth. We used repeated measures of weight and height in the first 5 years of life to model individual postnatal growth trajectories. We estimated adjusted variations in pre and postnatal growth parameters associated with an inter quartile range increase in In-transformed phthalate metabolite concentrations. Results: Monocarboxyisononyl phthalate (MCNP) was positively associated with femoral length during gestation and length at birth. High molecular weight phthalate metabolites were negatively associated with estimated fetal weight throughout pregnancy. Monoethyl phthalate (MEP) showed positive association with weight growth velocity from two to five years and with body mass index at five years (beta=0.17 kg/m(2), 95% confidence interval, 0.04, 0.30). Conclusions: We highlighted associations between gestational exposure to some phthalates and growth in boys. The positive association between MEP and postnatal growth in boys was also reported in several previous human studies. (C) 2016 Elsevier Inc. All rights reserved.
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