期刊
NANOMATERIALS
卷 11, 期 2, 页码 -出版社
MDPI
DOI: 10.3390/nano11020460
关键词
curcumin; metal oxide nanoparticles; nanoformulations; biomedical applications
类别
资金
- Korea Research Fellowship Program through the National Research Foundation of Korea (NRF) - Ministry of Science, ICT and Future Planning [2020H1D3 A1A04070539]
- Basic Science Research Program through the National Research Foundation of Korea (NRF) - Ministry of Science, ICT and Future Planning [2017R1A2B2007741]
- National Research Foundation of Korea [2017R1A2B2007741] Funding Source: Korea Institute of Science & Technology Information (KISTI), National Science & Technology Information Service (NTIS)
Researchers believe that curcumin has the potential to become a potential therapeutic agent for multiple diseases, but its inherent limitations have hindered its application. Many studies have been conducted to overcome the issues with curcumin. While organic nanocarriers have been extensively studied, research on curcumin nanoformulation with inorganic nanomaterials remains limited.
In the past few decades, curcumin, a natural polyphenolic phytochemical, has been studied for treating a wide variety of diseases. It has shown promising results as a potential curative agent for a variety of diseases. However, its inherent limitations, such as poor aqueous solubility, poor absorbability, fast metabolic rate, and quick elimination from the body, have limited its application beyond preclinical studies. A huge number of studies have been made to address the issues of curcumin and to maximally utilize its potentials. Many review articles have tried to assess and summarize different nanocarriers, especially organic nanocarriers, for nanoformulations with curcumin. Nevertheless, few exclusive reviews on the progress in nanoformulation of curcumin with inorganic nanomaterials have been made. In this review, we present an exclusive summary of the progress in nanoformulation of curcumin with metal oxide nanoparticles. The beneficial feature of the metal oxide nanoparticles used in the curcumin nanoformulation, the different approaches followed in formulating curcumin with the metal oxides, and the corresponding results, protective effect of curcumin from different metal oxide caused toxicities, and concluding remarks are presented in the review.
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