4.7 Review

Impact of Microplastics and Nanoplastics on Human Health

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Summary: The field of nanotechnology has rapidly grown over the past two decades, leading to the emergence of nanoparticles as promising tools in various applications. However, questions about the toxicity and safety of nanoparticles remain unanswered, despite efforts to understand them. Several approaches to minimize and prevent nanoparticle toxicity have been identified through research.

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Understanding the interactions of poly(methyl methacrylate) and poly(vinyl chloride) nanoparticles with BHK-21 cell line

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Summary: Studies have shown that PVC and PMMA nanoparticles can affect cell viability, decrease ATP levels, and increase ROS concentrations. These plastic nanoparticles are internalized into cells through endocytosis, potentially disrupting cellular physiology in a negative manner.

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Review Environmental Sciences

Potential human health risks due to environmental exposure to nano-and microplastics and knowledge gaps: A scoping review

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Summary: Microplastics are an emerging global environmental contaminant that may have negative impacts on human health through various pathways such as metabolic disturbances, neurotoxicity, and increased cancer risk. Currently, little is known about the effects of microplastics on human health, and further research is needed to quantify their impacts and pathogenesis.

SCIENCE OF THE TOTAL ENVIRONMENT (2021)

Article Environmental Sciences

Induction of protective response to polystyrene nanoparticles associated with dysregulation of intestinal long non-coding RNAs in Caenorhabditis elegans

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Summary: Intestinal barrier in nematode Caenorhabditis elegans plays a crucial role in response to polystyrene nanoparticles (PS-NPs) by controlling specific long non-coding RNAs (lncRNAs). These lncRNAs regulate transcription factors to mediate a protective response to PS-NPs.

ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY (2021)

Review Environmental Sciences

A review of human and animals exposure to polycyclic aromatic hydrocarbons: Health risk and adverse effects, photo-induced toxicity and regulating effect of microplastics

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Summary: PAHs are widely distributed persistent organic pollutants in the environment, with major sources being incomplete combustion of fossil fuels and municipal waste incineration. Exposure to PAHs can lead to various adverse effects including carcinogenicity and genotoxicity.

SCIENCE OF THE TOTAL ENVIRONMENT (2021)

Review Biochemistry & Molecular Biology

Potent Impact of Plastic Nanomaterials and Micromaterials on the Food Chain and Human Health

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Review Environmental Sciences

Environmental exposure to microplastics: An overview on possible human health effects

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SCIENCE OF THE TOTAL ENVIRONMENT (2020)

Review Environmental Sciences

A Detailed Review Study on Potential Effects of Microplastics and Additives of Concern on Human Health

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Microbial degradation and other environmental aspects of microplastics/plastics

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Where is the evidence that human exposure to microplastics is safe?

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Assessment of Human Health Risks Posed by Nano-and Microplastics Is Currently Not Feasible

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Review Chemistry, Multidisciplinary

Micro- and nanoplastics - current state of knowledge with the focus on oral uptake and toxicity

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Plastic pollution in the marine environment

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HELIYON (2020)

Review Public, Environmental & Occupational Health

Health effects of ultrafine particles: a systematic literature review update of epidemiological evidence

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Impacts of polystyrene microplastic on the gut barrier, microbiota and metabolism of mice

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Things we know and don't know about nanoplastic in the environment

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Article Engineering, Environmental

Human Consumption of Microplastics

Kieran D. Cox et al.

ENVIRONMENTAL SCIENCE & TECHNOLOGY (2019)

Review Engineering, Environmental

Emergence of Nanoplastic in the Environment and Possible Impact on Human Health

Roman Lehner et al.

ENVIRONMENTAL SCIENCE & TECHNOLOGY (2019)

Article Environmental Sciences

Organic pollutants in marine plastic debris from Canary Islands beaches

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SCIENCE OF THE TOTAL ENVIRONMENT (2019)

Review Environmental Sciences

Toxicological considerations of nano-sized plastics

P. A. Stapleton

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Ultrahigh molecular weight polyethylene/graphene oxide nanocomposites: Wear characterization and biological response to wear particles

S. Suner et al.

JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART B-APPLIED BIOMATERIALS (2018)

Article Environmental Sciences

Adsorption of antibiotics on microplastics

Jia Li et al.

ENVIRONMENTAL POLLUTION (2018)

Review Environmental Sciences

Airborne microplastics: Consequences to human health?

Joana Correia Prata

ENVIRONMENTAL POLLUTION (2018)

Editorial Material Environmental Sciences

Current opinion: What is a nanoplastic?

Julien Gigault et al.

ENVIRONMENTAL POLLUTION (2018)

Review Cell Biology

Mechanisms of clathrin-mediated endocytosis

Marko Kaksonen et al.

NATURE REVIEWS MOLECULAR CELL BIOLOGY (2018)

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Anthropogenic contamination of tap water, beer, and sea salt

Mary Kosuth et al.

PLOS ONE (2018)

Article Environmental Sciences

Polystyrene microplastics induce gut microbiota dysbiosis and hepatic lipid metabolism disorder in mice

Liang Lu et al.

SCIENCE OF THE TOTAL ENVIRONMENT (2018)

Article Environmental Sciences

Adherence of microplastics to soft tissue of mussels: A novel way to uptake microplastics beyond ingestion

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SCIENCE OF THE TOTAL ENVIRONMENT (2018)

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A critical perspective on early communications concerning human health aspects of microplastics

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SCIENCE OF THE TOTAL ENVIRONMENT (2018)

Article Chemistry, Physical

The Role of Mucin in the Toxicological Impact of Polystyrene Nanoparticles

Iwona Inkielewicz-Stepniak et al.

MATERIALS (2018)

Review Environmental Sciences

Metabolomics: a tool to characterize the effect of phthalates and bisphenol A

Cristina Gomez et al.

ENVIRONMENTAL REVIEWS (2018)

Article Biotechnology & Applied Microbiology

Potential role of LINC00996 in colorectal cancer : a study based on data mining and bioinformatics

Hua Ge et al.

ONCOTARGETS AND THERAPY (2018)

Article Chemistry, Multidisciplinary

Synthetic Polymer Contamination in Bottled Water

Sherri A. Mason et al.

FRONTIERS IN CHEMISTRY (2018)

Review Environmental Sciences

Occurrence, sources, human health impacts and mitigation of microplastic pollution

Samaneh Karbalaei et al.

ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH (2018)

Article Environmental Sciences

A first overview of textile fibers, including microplastics, in indoor and outdoor environments

Rachid Dris et al.

ENVIRONMENTAL POLLUTION (2017)

Article Engineering, Environmental

Nanoplastic in the North Atlantic Subtropical Gyre

Alexandra Ter Halle et al.

ENVIRONMENTAL SCIENCE & TECHNOLOGY (2017)

Review Engineering, Environmental

Plastic and Human Health: A Micro Issue?

Stephanie L. Wright et al.

ENVIRONMENTAL SCIENCE & TECHNOLOGY (2017)

Article Engineering, Environmental

Combined Effects of UV Exposure Duration and Mechanical Abrasion on Microplastic Fragmentation by Polymer Type

Young Kyoung Song et al.

ENVIRONMENTAL SCIENCE & TECHNOLOGY (2017)

Article Environmental Sciences

Microplastics as a vector for the transport of the bacterial fish pathogen species Aeromonas salmonicida

Manca Kovac Virsek et al.

MARINE POLLUTION BULLETIN (2017)

Article Engineering, Environmental

Are There Nanoplastics in Your Personal Care Products?

Laura M. Hernandez et al.

ENVIRONMENTAL SCIENCE & TECHNOLOGY LETTERS (2017)

Article Environmental Sciences

Microplastics as contaminants in commercially important seafood species

David Santillo et al.

INTEGRATED ENVIRONMENTAL ASSESSMENT AND MANAGEMENT (2017)

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The presence of microplastics in commercial salts from different countries

Ali Karami et al.

SCIENTIFIC REPORTS (2017)

Article Environmental Sciences

Characterisation of nanoplastics during the degradation of polystyrene

Scott Lambert et al.

CHEMOSPHERE (2016)

Editorial Material Engineering, Environmental

Plastic Debris Is a Human Health Issue

A. Dick Vethaak et al.

ENVIRONMENTAL SCIENCE & TECHNOLOGY (2016)

Article Biochemical Research Methods

Secreted protein eco-corona mediates uptake and impacts of polystyrene nanoparticles on Daphnia magna

Fatima Nasser et al.

JOURNAL OF PROTEOMICS (2016)

Article Environmental Sciences

Synthetic fibers in atmospheric fallout: A source of microplastics in the environment?

Rachid Dris et al.

MARINE POLLUTION BULLETIN (2016)

Article Toxicology

Endocytosed nanoparticles hold endosomes and stimulate binucleated cells formation

Lin Xia et al.

PARTICLE AND FIBRE TOXICOLOGY (2016)

Article Toxicology

Polystyrene nanoparticles internalization in human gastric adenocarcinoma cells

Maurizio Forte et al.

TOXICOLOGY IN VITRO (2016)

Article Food Science & Technology

Presence of microplastics and nanoplastics in food, with particular focus on seafood

Jan Alexander et al.

EFSA JOURNAL (2016)

Article Environmental Sciences

Qualitative Analysis of Additives in Plastic Marine Debris and Its New Products

Manviri Rani et al.

ARCHIVES OF ENVIRONMENTAL CONTAMINATION AND TOXICOLOGY (2015)

Article Environmental Sciences

Microplastics in commercial bivalves from China

Jiana Li et al.

ENVIRONMENTAL POLLUTION (2015)

Article Engineering, Environmental

Microplastic Pollution in Table Salts from China

Dongqi Yang et al.

ENVIRONMENTAL SCIENCE & TECHNOLOGY (2015)

Article Environmental Sciences

Ingestion of microplastics by commercial fish off the Portuguese coast

Diogo Neves et al.

MARINE POLLUTION BULLETIN (2015)

Review Biology

Linking effects of anthropogenic debris to ecological impacts

Mark Anthony Browne et al.

PROCEEDINGS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES (2015)

Article Multidisciplinary Sciences

Plastic waste inputs from land into the ocean

Jenna R. Jambeck et al.

SCIENCE (2015)

Article Nanoscience & Nanotechnology

Nanotechnology in the real world: Redeveloping the nanomaterial consumer products inventory

Marina E. Vance et al.

BEILSTEIN JOURNAL OF NANOTECHNOLOGY (2015)

Article Cell Biology

Nano-sized and micro-sized polystyrene particles affect phagocyte function

B. Prietl et al.

CELL BIOLOGY AND TOXICOLOGY (2014)

Article Environmental Sciences

Leaching of plastic additives to marine organisms

Albert A. Koelmans et al.

ENVIRONMENTAL POLLUTION (2014)

Review Engineering, Environmental

Interactions of Dissolved Organic Matter with Natural and Engineered Inorganic Colloids: A Review

Allan Philippe et al.

ENVIRONMENTAL SCIENCE & TECHNOLOGY (2014)

Article Chemistry, Applied

Synthetic particles as contaminants in German beers

Gerd Liebezeit et al.

FOOD ADDITIVES AND CONTAMINANTS PART A-CHEMISTRY ANALYSIS CONTROL EXPOSURE & RISK ASSESSMENT (2014)

Article Chemistry, Physical

Polystyrene Nanoparticles Perturb Lipid Membranes

Giulia Rossi et al.

JOURNAL OF PHYSICAL CHEMISTRY LETTERS (2014)

Article Multidisciplinary Sciences

Plastic debris in the open ocean

Andres Cozar et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2014)

Article Developmental Biology

Bisphenol A modulates the metabolic regulator oestrogen-related receptor-α in T-cells

Riccardo Cipelli et al.

REPRODUCTION (2014)

Article Nanoscience & Nanotechnology

Different endocytotic uptake mechanisms for nanoparticles in epithelial cells and macrophages

Dagmar A. Kuhn et al.

BEILSTEIN JOURNAL OF NANOTECHNOLOGY (2014)

Article Environmental Sciences

Risk assessments of human exposure to bioaccessible phthalate esters through market fish consumption

Zhang Cheng et al.

ENVIRONMENT INTERNATIONAL (2013)

Article Engineering, Environmental

Plastic as a Carrier of POPs to Aquatic Organisms: A Model Analysis

Albert A. Koelmans et al.

ENVIRONMENTAL SCIENCE & TECHNOLOGY (2013)

Article Engineering, Environmental

Life in the Plastisphere: Microbial Communities on Plastic Marine Debris

Erik R. Zettler et al.

ENVIRONMENTAL SCIENCE & TECHNOLOGY (2013)

Article Chemistry, Applied

Non-pollen particulates in honey and sugar

Gerd Liebezeit et al.

FOOD ADDITIVES AND CONTAMINANTS PART A-CHEMISTRY ANALYSIS CONTROL EXPOSURE & RISK ASSESSMENT (2013)

Review Pharmacology & Pharmacy

Skin penetration enhancers

Majella E. Lane

INTERNATIONAL JOURNAL OF PHARMACEUTICS (2013)

Editorial Material Multidisciplinary Sciences

Classify plastic waste as hazardous

Chelsea M. Rochman et al.

NATURE (2013)

Article Nanoscience & Nanotechnology

Rapid formation of plasma protein corona critically affects nanoparticle pathophysiology

Stefan Tenzer et al.

NATURE NANOTECHNOLOGY (2013)

Review Engineering, Environmental

The Complex Interaction between Marine Debris and Toxic Chemicals in the Ocean

Richard E. Engler

ENVIRONMENTAL SCIENCE & TECHNOLOGY (2012)

Review Nanoscience & Nanotechnology

The role of surface charge in cellular uptake and cytotoxicity of medical nanoparticles

Eleonore Froehlich

INTERNATIONAL JOURNAL OF NANOMEDICINE (2012)

Article Chemistry, Multidisciplinary

Objective assessment of nanoparticle disposition in mammalian skin after topical exposure

Christopher S. J. Campbell et al.

JOURNAL OF CONTROLLED RELEASE (2012)

Article Nanoscience & Nanotechnology

Oral exposure to polystyrene nanoparticles affects iron absorption

Gretchen J. Mahler et al.

NATURE NANOTECHNOLOGY (2012)

Article Toxicology

Action of polystyrene nanoparticles of different sizes on lysosomal function and integrity

Eleonore Froehlich et al.

PARTICLE AND FIBRE TOXICOLOGY (2012)

Article Multidisciplinary Sciences

Solar UV radiation reduces the barrier function of human skin

Krysta Biniek et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2012)

Review Cell Biology

Morphological aspects of interactions between microparticles and mammalian cells: intestinal uptake and onward movement

Katharine E. Carr et al.

PROGRESS IN HISTOCHEMISTRY AND CYTOCHEMISTRY (2012)

Article Biotechnology & Applied Microbiology

Quantifying size-dependent interactions between fluorescently labeled polystyrene nanoparticles and mammalian cells

Juan A. Varela et al.

JOURNAL OF NANOBIOTECHNOLOGY (2012)

Review Chemistry, Multidisciplinary

Nanotoxicology: An Interdisciplinary Challenge

Harald F. Krug et al.

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2011)

Review Chemistry, Multidisciplinary

Protein-Nanoparticle Interactions: Opportunities and Challenges

Morteza Mahmoudi et al.

CHEMICAL REVIEWS (2011)

Article Environmental Sciences

Environmental and health effects of nanomaterials in nanotextiles and facade coatings

Claudia Som et al.

ENVIRONMENT INTERNATIONAL (2011)

Article Engineering, Environmental

Accumulation of Microplastic on Shorelines Woldwide: Sources and Sinks

Mark Anthony Browne et al.

ENVIRONMENTAL SCIENCE & TECHNOLOGY (2011)

Article Nanoscience & Nanotechnology

Polystyrene nanoparticles activate ion transport in human airway epithelial cells

J. McCarthy et al.

INTERNATIONAL JOURNAL OF NANOMEDICINE (2011)

Article Nanoscience & Nanotechnology

Polystyrene nanoparticle trafficking across MDCK-II

Farnoosh Fazlollahi et al.

NANOMEDICINE-NANOTECHNOLOGY BIOLOGY AND MEDICINE (2011)

Article Nanoscience & Nanotechnology

Experimental and theoretical comparison of intracellular import of polymeric nanoparticles and small molecules: toward models of uptake kinetics

Anna Salvati et al.

NANOMEDICINE-NANOTECHNOLOGY BIOLOGY AND MEDICINE (2011)

Review Environmental Sciences

Microplastics as contaminants in the marine environment: A review

Matthew Cole et al.

MARINE POLLUTION BULLETIN (2011)

Review Environmental Sciences

Microplastics in the marine environment

Anthony L. Andrady

MARINE POLLUTION BULLETIN (2011)

Review Biochemistry & Molecular Biology

Mechanisms of Endocytosis

Gary J. Doherty et al.

ANNUAL REVIEW OF BIOCHEMISTRY (2009)

Article Environmental Sciences

Plastics and beaches: A degrading relationship

Patricia L. Corcoran et al.

MARINE POLLUTION BULLETIN (2009)

Article Pharmacology & Pharmacy

In vivo pharmacokinetics, tissue distribution and underlying mechanisms of various PEI(-PEG)/siRNA complexes

Anastasia Malek et al.

TOXICOLOGY AND APPLIED PHARMACOLOGY (2009)

Review Dermatology

Nanoparticles and their interactions with the dermal barrier

Marc Schneider et al.

DERMATO-ENDOCRINOLOGY (2009)

Review Environmental Sciences

Polymer biodegradation: Mechanisms and estimation techniques

Nathalie Lucas et al.

CHEMOSPHERE (2008)

Article Environmental Sciences

Exposure of the US population to bisphenol A and 4-tertiary-octylphenol: 2003-2004

Antonia M. Calafat et al.

ENVIRONMENTAL HEALTH PERSPECTIVES (2008)

Article Andrology

Bisphenol-A disruption of the endocrine pancreas and blood glucose homeostasis

A. B. Ropero et al.

INTERNATIONAL JOURNAL OF ANDROLOGY (2008)

Article Medicine, General & Internal

Association of urinary bisphenol A concentration with medical disorders and laboratory abnormalities in adults

Iain A. Lang et al.

JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION (2008)

Article Chemistry, Multidisciplinary

In vivo skin penetration of quantum dot nanoparticles in the murine model:: The effect of UVR

Luke J. Mortensen et al.

NANO LETTERS (2008)

Article Nanoscience & Nanotechnology

Polystyrene nanoparticle trafficking across alveolar epithelium

Nazanin R. Yacobi et al.

NANOMEDICINE-NANOTECHNOLOGY BIOLOGY AND MEDICINE (2008)

Article Multidisciplinary Sciences

Nanoparticle size and surface properties determine the protein corona with possible implications for biological impacts

Martin Lundqvist et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2008)

Review Reproductive Biology

An ecological assessment of bisphenol-A: Evidence from comparative biology

D. Andrew Crain et al.

REPRODUCTIVE TOXICOLOGY (2007)

Article Pharmacology & Pharmacy

An improved in vitro model of human intestinal follicle-associated epithelium to study nanoparticle transport by M cells

Anne des Rieux et al.

EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES (2007)

Article Chemistry, Multidisciplinary

Skin penetration and distribution of polymeric nanoparticles

R Alvarez-Román et al.

JOURNAL OF CONTROLLED RELEASE (2004)

Article Endocrinology & Metabolism

Thyroid hormone action is disrupted by bisphenol A as an antagonist

K Moriyama et al.

JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM (2002)

Article Dermatology

New aspects of the skin barrier organization

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SKIN PHARMACOLOGY AND APPLIED SKIN PHYSIOLOGY (2001)