期刊
NANOMATERIALS
卷 11, 期 2, 页码 -出版社
MDPI
DOI: 10.3390/nano11020477
关键词
mesoporous silica; silver; nanocomposite; cetyltrimethylammonium bromide; antibacterial activity
类别
资金
- NPO Young Researchers Alliance
- Nazarbayev University Corporate Fund Social Development Fund
The study demonstrated a highly efficient antibacterial nanocomposite by attaching silver nanoparticles to the surface of cetyltrimethylammonium bromide (CTAB)-loaded mesoporous silica nanoparticles. The improved antibacterial activity of the prepared nanocomposite can be attributed to the even distribution of non-aggregated silver nanoparticles per volume unit and the presence of CTAB in the nanocomposite pores.
To date, Ag-based nanomaterials have demonstrated a high potential to overcome antibiotic resistance issues. However, bare Ag nanomaterials are prone to agglomeration in the biological environment, which results in a loss of antibacterial activity over time. Furthermore, it is still challenging to collect small-sized Ag nanomaterials right after the synthesis process. In this study, spherical-shaped Ag nanoparticles (NPs) (similar to 6-10 nm) were attached on the surface of cetyltrimethylammonium bromide (CTAB)-loaded mesoporous silica nanoparticles (MSNs) (similar to 100-110 nm). Antibacterial activity tests suggested that the obtained nanocomposite can be used as a highly efficient antibacterial agent against both Gram-negative and Gram-positive bacterial strains. The minimum inhibitory concentration (MIC) recalculated to pure Ag weight in nanocomposite was found to be similar to 1.84 mu g/mL (for Escherichia colt) and similar to 0.92 mu g/mL (for Staphylococcus aureus)-significantly smaller compared to values reported to date. The improved antibacterial activity of the prepared nanocomposite can be attributed to the even distribution of non-aggregated Ag NPs per volume unit and the presence of CTAB in the nanocomposite pores.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据